PRKD2

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Protein kinase D2
Protein PRKD2 PDB 2coa.png
PDB rendering based on 2coa.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PRKD2 ; PKD2; nPKC-D2
External IDs OMIM607074 MGI2141917 HomoloGene9516 ChEMBL: 4900 GeneCards: PRKD2 Gene
EC number 2.7.11.13
RNA expression pattern
PBB GE PRKD2 209282 at tn.png
PBB GE PRKD2 38269 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25865 101540
Ensembl ENSG00000105287 ENSMUSG00000041187
UniProt Q9BZL6 Q8BZ03
RefSeq (mRNA) NM_001079880 NM_001252458
RefSeq (protein) NP_001073349 NP_001239387
Location (UCSC) Chr 19:
47.18 – 47.22 Mb
Chr 7:
16.84 – 16.87 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase D2 or protein kinase C δ2 (PKC-δ2) is an enzyme that in humans is encoded by the PRKD2 gene.[1][2][3]

Function[edit]

The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases, a subfamily of protein kinase c. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms.[3]

References[edit]

  1. ^ Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152. 
  2. ^ Sturany S, Van Lint J, Muller F, Wilda M, Hameister H, Hocker M, Brey A, Gern U, Vandenheede J, Gress T, Adler G, Seufferlein T (May 2001). "Molecular cloning and characterization of the human protein kinase D2. A novel member of the protein kinase D family of serine threonine kinases". J Biol Chem 276 (5): 3310–8. doi:10.1074/jbc.M008719200. PMID 11062248. 
  3. ^ a b "Entrez Gene: PRKD2 protein kinase D2". 

Further reading[edit]