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Protein kinase D3
Protein PRKD3 PDB 2d9z.png
PDB rendering based on 2d9z.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM607077 MGI1922542 HomoloGene2055 IUPHAR: 2174 ChEMBL: 2595 GeneCards: PRKD3 Gene
EC number
RNA expression pattern
PBB GE PRKD3 218236 s at tn.png
PBB GE PRKD3 211084 x at tn.png
More reference expression data
Species Human Mouse
Entrez 23683 75292
Ensembl ENSG00000115825 ENSMUSG00000024070
UniProt O94806 Q8K1Y2
RefSeq (mRNA) NM_005813 NM_001171004
RefSeq (protein) NP_005804 NP_001164475
Location (UCSC) Chr 2:
37.48 – 37.55 Mb
Chr 17:
78.95 – 79.02 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase D3 or protein kinase C δ3 (PKC-δ3) is an enzyme that in humans is encoded by the PRKD3 gene.[1][2]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role. The protein encoded by this gene is one of the PKC family members. This kinase can be activated rapidly by the agonists of G protein-coupled receptors. It resides in both cytoplasm and nucleus, and its nuclear accumulation is found to be dramatically enhanced in response to its activation. This kinase can also be activated after B-cell antigen receptor (BCR) engagement, which requires intact phospholipase C gamma and the involvement of other PKC family members.[2]


  1. ^ Hayashi A, Seki N, Hattori A, Kozuma S, Saito T (Jun 1999). "PKCnu, a new member of the protein kinase C family, composes a fourth subfamily with PKCmu". Biochim Biophys Acta 1450 (1): 99–106. doi:10.1016/S0167-4889(99)00040-3. PMID 10231560. 
  2. ^ a b "Entrez Gene: PRKD3 protein kinase D3". 

Further reading[edit]