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Protein kinase, interferon-inducible double stranded RNA dependent activator
Protein PRKRA PDB 2dix.png
PDB rendering based on 2dix.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRKRA ; DYT16; PACT; RAX
External IDs OMIM603424 MGI1344375 HomoloGene2738 GeneCards: PRKRA Gene
RNA expression pattern
PBB GE PRKRA 209139 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8575 23992
Ensembl ENSG00000180228 ENSMUSG00000002731
UniProt O75569 Q9WTX2
RefSeq (mRNA) NM_001139517 NM_011871
RefSeq (protein) NP_001132989 NP_036001
Location (UCSC) Chr 2:
179.3 – 179.32 Mb
Chr 2:
76.63 – 76.65 Mb
PubMed search [1] [2]

Protein kinase, interferon-inducible double stranded RNA dependent activator, also known as interferon-inducible double stranded RNA-dependent protein kinase activator A or Protein ACTivator of the interferon-induced protein kinase (PACT) is a protein that in humans is encoded by the PRKRA gene.[1][2][3] PACT heterodimerizes with and activates protein kinase R.[2][4] PRKRA mutations have been linked to a rare form of dystonia parkinsonism. [5]


  1. ^ "Entrez Gene: PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator". 
  2. ^ a b Patel RC, Sen GC (August 1998). "PACT, a protein activator of the interferon-induced protein kinase, PKR". EMBO J. 17 (15): 4379–90. doi:10.1093/emboj/17.15.4379. PMC 1170771. PMID 9687506. 
  3. ^ Ito T, Yang M, May WS (May 1999). "RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling". J. Biol. Chem. 274 (22): 15427–32. doi:10.1074/jbc.274.22.15427. PMID 10336432. 
  4. ^ Huang X, Hutchins B, Patel RC (August 2002). "The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR)". Biochem. J. 366 (Pt 1): 175–86. doi:10.1042/BJ20020204. PMC 1222748. PMID 11985496. 
  5. ^ Camargos S, Scholz S, Simón-Sánchez J, Paisán-Ruiz C, Lewis P, Hernandez D, Ding J, Gibbs JR, Cookson MR, Bras J, Guerreiro R, Oliveira CR, Lees A, Hardy J, Cardoso F, Singleton AB (March 2008). "DYT16, a novel young-onset dystonia-parkinsonism disorder: identification of a segregating mutation in the stress-response protein PRKRA". Lancet Neurology 7 (3): 207–215. doi:10.1016/S1474-4422(08)70022-X. PMID 18243799. 

Further reading[edit]