PRO-LAD

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PRO-LAD
PRO-LAD structure.png
Systematic (IUPAC) name
(8β)-N,N-Diethyl-6-propyl-9,10-didehydroergoline-8-carboxamide
Clinical data
Legal status Controlled in the United States via the Federal Analog Act but only if it is intended for human consumption.
Routes Oral
Pharmacokinetic data
Metabolism hepatic
Excretion renal
Identifiers
CAS number 65527-63-1 YesY
ATC code ?
PubChem CID 44457803
ChemSpider 21106361 YesY
ChEMBL CHEMBL22258 YesY
Synonyms PRO-LAD,
6-propyl- 6-nor- Lysergic acid diethylamide,
(6aR,9R)- N,N- diethyl- 7-propyl- 4,6,6a,7,8,9- hexahydroindolo- [4,3-fg] quinoline- 9- carboxamide
Chemical data
Formula C22H29N3O 
Mol. mass 351.50 g/mol
 YesY (what is this?)  (verify)

PRO-LAD is an analogue of LSD. It is described by Alexander Shulgin in the book TiHKAL. PRO-LAD is a psychedelic drug similar to LSD, and is around as potent as LSD itself with an active dose reported at between 100 and 200 micrograms.[1]

Literature[edit]

  • Andrew J. Hoffman, David E. Nichols: Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives. In: Journal of Medicinal Chemistry. 28, 1985, p. 1252–1255, doi:10.1021/jm00147a022.
  • T. Niwaguchi, Y. Nakahara, H. Ishii: Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds. In: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. Vol. 96, No. 5, May 1976, p. 673–678, PMID 987200.
  • Robert C. Pfaff, Xuemei Huang, Danuta Marona-Lewicka, Robert Oberlender and David E. Nichols: Lysergamides Revisited. In: NIDA Research Monograph 146: Hallucinogens: An Update. p. 52, 1994, United States Department of Health and Human Services.

See also[edit]

References[edit]

  1. ^ Hoffman AJ, Nichols DE (September 1985). "Synthesis and LSD-like discriminative stimulus properties in a series of N(6)-alkyl norlysergic acid N,N-diethylamide derivatives". Journal of Medicinal Chemistry 28 (9): 1252–5. doi:10.1021/jm00147a022. PMID 4032428. 

External links[edit]