Protoporphyrinogen oxidase

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protoporphyrinogen oxidase
Identifiers
EC number 1.3.3.4
CAS number 53986-32-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO
protoporphyrinogen oxidase
Identifiers
Symbol PPOX
Alt. symbols VP
Entrez 5498
HUGO 9280
OMIM 600923
RefSeq NM_000309
UniProt P50336
Other data
Locus Chr. 1 q22

Protoporphyrinogen oxidase (EC 1.3.3.4) is an enzyme that is responsible for the seventh step in biosynthesis of protoporphyrin IX. This porphyrin is the precursor to hemoglobin, the oxygen carrier in animals, and chlorophyll, the dye in plants. The enzyme catalyzes the dehydrogenation (removal of hydrogen atoms) of protoporphyrinogen IX (the product of the sixth step in the production of heme) to form protoporphyrin IX. One additional enzyme must modify protoporphyrin IX before it becomes heme. Inhibition of this enzyme is a strategy used in certain herbicides.


Heme synthesis—note that some reactions occur in the cytoplasm and some in the mitochondrion (yellow)

See also[edit]