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Prospero homeobox 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbol PROX1
External IDs OMIM601546 MGI97772 HomoloGene2069 GeneCards: PROX1 Gene
RNA expression pattern
PBB GE PROX1 207401 at tn.png
More reference expression data
Species Human Mouse
Entrez 5629 19130
Ensembl ENSG00000117707 ENSMUSG00000010175
UniProt Q92786 P48437
RefSeq (mRNA) NM_001270616 NM_008937
RefSeq (protein) NP_001257545 NP_032963
Location (UCSC) Chr 1:
214.16 – 214.21 Mb
Chr 1:
190.12 – 190.17 Mb
PubMed search [1] [2]

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene.[1][2]


PROX1 has been shown to interact with EP300.[3]


PROX1 is produced primarily in the dentate gyrus in the mouse, and in the dentate gyrus and white matter in humans. Gene expression data for mouse, human and macaque from the Allen Brain Atlases can be found here.


  1. ^ Zinovieva RD, Duncan MK, Johnson TR, Torres R, Polymeropoulos MH, Tomarev SI (Dec 1996). "Structure and chromosomal localization of the human homeobox gene Prox 1". Genomics 35 (3): 517–22. doi:10.1006/geno.1996.0392. PMID 8812486. 
  2. ^ "Entrez Gene: PROX1 prospero-related homeobox 1". 
  3. ^ Chen, Qin; Dowhan Dennis H; Liang Dongcai; Moore David D; Overbeek Paul A (Jul 2002). "CREB-binding protein/p300 co-activation of crystallin gene expression". J. Biol. Chem. (United States) 277 (27): 24081–9. doi:10.1074/jbc.M201821200. ISSN 0021-9258. PMID 11943779. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.