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Pre-mRNA processing factor 3
Protein PRPF3 PDB 1x4q.png
PDB rendering based on 1x4q.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRPF3 ; HPRP3; HPRP3P; PRP3; Prp3p; RP18; SNRNP90
External IDs OMIM607301 MGI1918017 HomoloGene3447 GeneCards: PRPF3 Gene
RNA expression pattern
PBB GE PRPF3 202251 at tn.png
More reference expression data
Species Human Mouse
Entrez 9129 70767
Ensembl ENSG00000117360 ENSMUSG00000015748
UniProt O43395 Q922U1
RefSeq (mRNA) NM_004698 NM_027541
RefSeq (protein) NP_004689 NP_081817
Location (UCSC) Chr 1:
150.32 – 150.35 Mb
Chr 3:
95.83 – 95.86 Mb
PubMed search [1] [2]

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.[1]

The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is one of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][1]


PRPF3 has been shown to interact with DVL3.[2]


  1. ^ a b "Entrez Gene: PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)". 
  2. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

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