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PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
Protein PRPF40A PDB 1uzc.png
PDB rendering based on 1uzc.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PRPF40A ; FBP-11; FBP11; FLAF1; FNBP3; HIP-10; HIP10; HYPA; NY-REN-6; Prp40
External IDs OMIM612941 MGI1860512 HomoloGene6377 GeneCards: PRPF40A Gene
RNA expression pattern
PBB GE PRPF40A 213729 at tn.png
PBB GE PRPF40A 214941 s at tn.png
PBB GE PRPF40A 218053 at tn.png
More reference expression data
Species Human Mouse
Entrez 55660 56194
Ensembl ENSG00000196504 ENSMUSG00000061136
UniProt O75400 Q9R1C7
RefSeq (mRNA) NM_017892 NM_018785
RefSeq (protein) NP_060362 NP_061255
Location (UCSC) Chr 2:
153.51 – 153.57 Mb
Chr 2:
53.13 – 53.19 Mb
PubMed search [1] [2]

Pre-mRNA-processing factor 40 homolog A is a protein that in humans is encoded by the PRPF40A gene.[1][2][3]


PRPF40A has been shown to interact with Huntingtin.[4]


  1. ^ Bedford MT, Reed R, Leder P (Sep 1998). "WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif". Proc Natl Acad Sci U S A 95 (18): 10602–7. doi:10.1073/pnas.95.18.10602. PMC 27941. PMID 9724750. 
  2. ^ Wiesner S, Stier G, Sattler M, Macias MJ (Dec 2002). "Solution structure and ligand recognition of the WW domain pair of the yeast splicing factor Prp40". J Mol Biol 324 (4): 807–22. doi:10.1016/S0022-2836(02)01145-2. PMID 12460579. 
  3. ^ "Entrez Gene: PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)". 
  4. ^ Faber, P W; Barnes G T; Srinidhi J; Chen J; Gusella J F; MacDonald M E (Sep 1998). "Huntingtin interacts with a family of WW domain proteins". Hum. Mol. Genet. (ENGLAND) 7 (9): 1463–74. doi:10.1093/hmg/7.9.1463. ISSN 0964-6906. PMID 9700202. 

Further reading[edit]