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Pre-mRNA processing factor 6
Symbols PRPF6 ; ANT-1; ANT1; C20orf14; Prp6; RP60; SNRNP102; TOM; U5-102K; hPrp6
External IDs OMIM613979 MGI1922946 HomoloGene5368 GeneCards: PRPF6 Gene
Species Human Mouse
Entrez 24148 68879
Ensembl ENSG00000101161 ENSMUSG00000002455
UniProt O94906 Q91YR7
RefSeq (mRNA) NM_012469 NM_133701
RefSeq (protein) NP_036601 NP_598462
Location (UCSC) Chr 20:
62.61 – 62.66 Mb
Chr 2:
181.59 – 181.66 Mb
PubMed search [1] [2]

Pre-mRNA-processing factor 6 is a protein that in humans is encoded by the PRPF6 gene.[1][2][3]

The protein encoded by this gene appears to be involved in pre-mRNA splicing, possibly acting as a bridging factor between U5 and U4/U6 snRNPs in formation of the spliceosome. The encoded protein also can bind androgen receptor, providing a link between transcriptional activation and splicing.[3]


PRPF6 has been shown to interact with TXNL4B,[4] ARAF[5][6] and Androgen receptor.[7]


  1. ^ Nishikimi A, Mukai J, Kioka N, Yamada M (January 2000). "A novel mammalian nuclear protein similar to Schizosaccharomyces pombe Prp1p/Zer1p and Saccharomyces cerevisiae Prp6p pre-mRNA splicing factors". Biochim Biophys Acta 1435 (1-2): 147–52. doi:10.1016/s0167-4838(99)00203-4. PMID 10561546. 
  2. ^ Makarov EM, Makarova OV, Achsel T, Luhrmann R (June 2000). "The human homologue of the yeast splicing factor prp6p contains multiple TPR elements and is stably associated with the U5 snRNP via protein-protein interactions". J Mol Biol 298 (4): 567–75. doi:10.1006/jmbi.2000.3685. PMID 10788320. 
  3. ^ a b "Entrez Gene: PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae)". 
  4. ^ Sun, Xiaojing; Zhang Hua; Wang Dan; Ma Dalong; Shen Yan; Shang Yongfeng (July 2004). "DLP, a novel Dim1 family protein implicated in pre-mRNA splicing and cell cycle progression". J. Biol. Chem. (United States) 279 (31): 32839–47. doi:10.1074/jbc.M402522200. ISSN 0021-9258. PMID 15161931. 
  5. ^ Yuryev, Anton; Wennogle Lawrence P (February 2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis". Genomics (United States) 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. ISSN 0888-7543. PMID 12620389. 
  6. ^ Yuryev, A; Ono M; Goff S A; Macaluso F; Wennogle L P (July 2000). "Isoform-specific localization of A-RAF in mitochondria". Mol. Cell. Biol. (UNITED STATES) 20 (13): 4870–8. doi:10.1128/MCB.20.13.4870-4878.2000. ISSN 0270-7306. PMC 85938. PMID 10848612. 
  7. ^ Zhao, Yue; Goto Kiminobu; Saitoh Masayuki; Yanase Toshihiko; Nomura Masatoshi; Okabe Taijiro; Takayanagi Ryoichi; Nawata Hajime (August 2002). "Activation function-1 domain of androgen receptor contributes to the interaction between subnuclear splicing factor compartment and nuclear receptor compartment. Identification of the p102 U5 small nuclear ribonucleoprotein particle-binding protein as a coactivator for the receptor". J. Biol. Chem. (United States) 277 (33): 30031–9. doi:10.1074/jbc.M203811200. ISSN 0021-9258. PMID 12039962. 

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