PSB-SB-1202

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PSB-SB-1202
PSB-SB-1202 structure.png
Systematic (IUPAC) name
7-pentyl-5-methoxy-3-(2-methoxybenzyl)-2H-chromen-2-one
Clinical data
Legal status
?
Identifiers
CAS number 1399049-60-5
ATC code ?
PubChem CID 70677953
Chemical data
Formula C23H26O4 
Mol. mass 366.45

PSB-SB-1202 is a coumarin derivative which is an agonist at the cannabinoid receptors CB1 and CB2, with a CB1 Ki of 32nM and a CB2 Ki of 49nM.[1] It is also a weak antagonist at the related receptor GPR55, with an IC50 of 6350nM, but has no significant affinity for GPR18.[2]

See also[edit]

References[edit]

  1. ^ Rempel V, Volz N, Hinz S, Karcz T, Meliciani I, Nieger M, Wenzel W, Bräse S, Müller CE. 7-Alkyl-3-benzylcoumarins: a versatile scaffold for the development of potent and selective cannabinoid receptor agonists and antagonists. Journal of Medicinal Chemistry. 2012 Sep 27;55(18):7967-77. PMID 22916707
  2. ^ Rempel, V.; Volz, N.; Gläser, F.; Nieger, M.; Bräse, S.; Müller, C. E. (2013). "Antagonists for the orphan G protein-coupled receptor GPR55 based on a coumarin scaffold". Journal of Medicinal Chemistry 56 (11): 130516144836005. doi:10.1021/jm4005175. PMID 23679955.  edit