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Cytohesin 3
Protein PSCD3 PDB 1bc9.png
PDB rendering based on 1bc9.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols CYTH3 ; ARNO3; GRP1; PSCD3
External IDs OMIM605081 MGI1335107 HomoloGene3116 GeneCards: CYTH3 Gene
RNA expression pattern
PBB GE PSCD3 206523 at tn.png
More reference expression data
Species Human Mouse
Entrez 9265 19159
Ensembl ENSG00000008256 ENSMUSG00000018001
UniProt O43739 O08967
RefSeq (mRNA) NM_004227 NM_001163548
RefSeq (protein) NP_004218 NP_001157020
Location (UCSC) Chr 7:
6.2 – 6.31 Mb
Chr 5:
143.62 – 143.71 Mb
PubMed search [1] [2]

Cytohesin-3 is a protein that in humans is encoded by the CYTH3 gene.[1][2]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Cytohesin family members have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. This encoded protein is involved in the control of Golgi structure and function, and it may have a physiological role in regulating ADP-ribosylation factor protein 6 (ARF) functions, in addition to acting on ARF1.[2]


  1. ^ Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, Czech MP (Apr 1997). "Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains". Science 275 (5308): 1927–30. doi:10.1126/science.275.5308.1927. PMID 9072969. 
  2. ^ a b "Entrez Gene: PSCD3 pleckstrin homology, Sec7 and coiled-coil domains 3". 

Further reading[edit]