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Cytohesin 4
Symbols CYTH4 ; CYT4; DJ63G5.1; PSCD4
External IDs OMIM606514 MGI2441702 HomoloGene22750 GeneCards: CYTH4 Gene
RNA expression pattern
PBB GE PSCD4 219183 s at tn.png
PBB GE PSCD4 211521 s at tn.png
More reference expression data
Species Human Mouse
Entrez 27128 72318
Ensembl ENSG00000100055 ENSMUSG00000018008
UniProt Q9UIA0 Q80YW0
RefSeq (mRNA) NM_013385 NM_028195
RefSeq (protein) NP_037517 NP_082471
Location (UCSC) Chr 22:
37.68 – 37.71 Mb
Chr 15:
78.6 – 78.62 Mb
PubMed search [1] [2]

Cytohesin-4 is a protein that in humans is encoded by the CYTH4 gene.[1][2]

This gene encodes a member of the cytohesin (CYTH) family, formerly known as the PSCD (pleckstrin homology, Sec7 and coiled-coil domains) family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of CYTHs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. CYTH4 exhibits GEP activity in vitro with both ARF1 and ARF5 but is inactive with ARF6. The CYTH4 and CYTH1 gene structures are very similar.[2]


  1. ^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP et al. (Dec 1999). "The DNA sequence of human chromosome 22". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  2. ^ a b "Entrez Gene: PSCD4 pleckstrin homology, Sec7 and coiled-coil domains 4". 

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