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Cytohesin 1 interacting protein
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM604448 MGI2183535 HomoloGene3167 GeneCards: CYTIP Gene
RNA expression pattern
PBB GE PSCDBP 209606 at tn.png
More reference expression data
Species Human Mouse
Entrez 9595 227929
Ensembl ENSG00000115165 ENSMUSG00000026832
UniProt O60759 Q91VY6
RefSeq (mRNA) NM_004288 NM_139200
RefSeq (protein) NP_004279 NP_631939
Location (UCSC) Chr 2:
158.27 – 158.35 Mb
Chr 2:
58.13 – 58.2 Mb
PubMed search [1] [2]

Cytohesin-interacting protein is a protein that in humans is encoded by the CYTIP gene.[1][2][3][4]

The protein encoded by this gene contains 2 leucine zipper domains and a putative C-terminal nuclear targeting signal, and it does not have any hydrophobic regions. This protein is expressed weakly in resting NK and T cells.[4]


  1. ^ Dixon B, Sahely B, Liu L, Pohajdak B (Jan 1994). "Cloning a cDNA from human NK/T cells which codes for an unusual leucine zipper containing protein". Biochim Biophys Acta 1216 (2): 321–4. doi:10.1016/0167-4781(93)90165-a. PMID 8241278. 
  2. ^ Kim HS (Jun 1999). "Assignment of the human B3-1 gene (PSCDBP) to chromosome 2 band q11.2 by radiation hybrid mapping". Cytogenet Cell Genet 84 (1-2): 95. doi:10.1159/000015226. PMID 10343115. 
  3. ^ Tang P, Cheng TP, Agnello D, Wu CY, Hissong BD, Watford WT, Ahn HJ, Galon J, Moss J, Vaughan M, O'Shea JJ, Gadina M (Mar 2002). "Cybr, a cytokine-inducible protein that binds cytohesin-1 and regulates its activity". Proc Natl Acad Sci USA 99 (5): 2625–9. doi:10.1073/pnas.052712999. PMC 122398. PMID 11867758. 
  4. ^ a b "Entrez Gene: PSCDBP pleckstrin homology, Sec7 and coiled-coil domains, binding protein". 

Further reading[edit]