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Proteasome (prosome, macropain) subunit, alpha type, 5
Protein PSMA5 PDB 1iru.png
PDB rendering based on 1iru.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PSMA5 ; PSC5; ZETA
External IDs OMIM176844 MGI1347009 HomoloGene2084 GeneCards: PSMA5 Gene
EC number
RNA expression pattern
PBB GE PSMA5 201274 at tn.png
More reference expression data
Species Human Mouse
Entrez 5686 26442
Ensembl ENSG00000143106 ENSMUSG00000068749
UniProt P28066 Q9Z2U1
RefSeq (mRNA) NM_001199772 NM_011967
RefSeq (protein) NP_001186701 NP_036097
Location (UCSC) Chr 1:
109.94 – 109.97 Mb
Chr 3:
108.26 – 108.28 Mb
PubMed search [1] [2]

Proteasome subunit alpha type-5 is a protein that in humans is encoded by the PSMA5 gene.[1][2]

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit.[2]


PSMA5 has been shown to interact with PLK1.[3]


  1. ^ DeMartino GN, Orth K, McCullough ML, Lee LW, Munn TZ, Moomaw CR, Dawson PA, Slaughter CA (Oct 1991). "The primary structures of four subunits of the human, high-molecular-weight proteinase, macropain (proteasome), are distinct but homologous". Biochim Biophys Acta 1079 (1): 29–38. doi:10.1016/0167-4838(91)90020-Z. PMID 1888762. 
  2. ^ a b "Entrez Gene: PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5". 
  3. ^ Feng, Y; Longo D L; Ferris D K (Jan 2001). "Polo-like kinase interacts with proteasomes and regulates their activity". Cell Growth Differ. (United States) 12 (1): 29–37. ISSN 1044-9523. PMID 11205743. 

Further reading[edit]