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Proteasome (prosome, macropain) 26S subunit, ATPase, 2
Symbols PSMC2 ; MSS1; Nbla10058; S7
External IDs OMIM154365 MGI109555 HomoloGene2096 GeneCards: PSMC2 Gene
RNA expression pattern
PBB GE PSMC2 201068 s at tn.png
PBB GE PSMC2 201067 at tn.png
More reference expression data
Species Human Mouse
Entrez 5701 19181
Ensembl ENSG00000161057 ENSMUSG00000028932
UniProt P35998 P46471
RefSeq (mRNA) NM_001204453 NM_011188
RefSeq (protein) NP_001191382 NP_035318
Location (UCSC) Chr 7:
102.98 – 103.01 Mb
Chr 5:
21.79 – 21.8 Mb
PubMed search [1] [2]

26S protease regulatory subunit 7 is an enzyme that in humans is encoded by the PSMC2 gene.[1][2][3]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with several of the basal transcription factors so, in addition to participation in proteasome functions, this subunit may participate in the regulation of transcription. This subunit may also compete with PSMC3 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex.[3]


PSMC2 has been shown to interact with PSMD5,[4][5] PSMC1,[5][6] NDC80[7] and PSMC4.[6][8]


  1. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (March 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  2. ^ Shibuya H, Irie K, Ninomiya-Tsuji J, Goebl M, Taniguchi T, Matsumoto K (July 1992). "New human gene encoding a positive modulator of HIV Tat-mediated transactivation". Nature 357 (6380): 700–2. doi:10.1038/357700a0. PMID 1377363. 
  3. ^ a b "Entrez Gene: PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  5. ^ a b Gorbea, C; Taillandier D; Rechsteiner M (January 2000). "Mapping subunit contacts in the regulatory complex of the 26 S proteasome. S2 and S5b form a tetramer with ATPase subunits S4 and S7". J. Biol. Chem. (UNITED STATES) 275 (2): 875–82. doi:10.1074/jbc.275.2.875. ISSN 0021-9258. PMID 10625621. 
  6. ^ a b Hartmann-Petersen, R; Tanaka K; Hendil K B (February 2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. (United States) 386 (1): 89–94. doi:10.1006/abbi.2000.2178. ISSN 0003-9861. PMID 11361004. 
  7. ^ Chen, Y; Sharp Z D; Lee W H (September 1997). "HEC binds to the seventh regulatory subunit of the 26 S proteasome and modulates the proteolysis of mitotic cyclins". J. Biol. Chem. (UNITED STATES) 272 (38): 24081–7. doi:10.1074/jbc.272.38.24081. ISSN 0021-9258. PMID 9295362. 
  8. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 

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