26S protease regulatory subunit 6A is an enzyme that in humans is encoded by the PSMC3gene.
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9.
^Hoyle J, Tan KH, Fisher EM (Mar 1997). "Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1)". Hum Genet99 (2): 285–8. doi:10.1007/s004390050356. PMID9048938.
^Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (Mar 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID9473509.
^Ishizuka, T; Satoh T; Monden T; Shibusawa N; Hashida T; Yamada M; Mori M (Aug 2001). "Human immunodeficiency virus type 1 Tat binding protein-1 is a transcriptional coactivator specific for TR". Mol. Endocrinol. (United States) 15 (8): 1329–43. doi:10.1210/me.15.8.1329. ISSN0888-8809. PMID11463857.
^Corn, Paul G; McDonald E Robert, Herman James G, El-Deiry Wafik S (Nov 2003). "Tat-binding protein-1, a component of the 26S proteasome, contributes to the E3 ubiquitin ligase function of the von Hippel-Lindau protein". Nat. Genet. (United States) 35 (3): 229–37. doi:10.1038/ng1254. ISSN1061-4036. PMID14556007.Cite uses deprecated parameters (help)
Nelbock P, Dillon PJ, Perkins A, Rosen CA (1990). "A cDNA for a protein that interacts with the human immunodeficiency virus Tat transactivator.". Science248 (4963): 1650–3. doi:10.1126/science.2194290. PMID2194290.
Shaw DR, Ennis HL (1993). "Molecular cloning and developmental regulation of Dictyostelium discoideum homologues of the human and yeast HIV1 Tat-binding protein". Biochem. Biophys. Res. Commun.193 (3): 1291–6. doi:10.1006/bbrc.1993.1765. PMID8323548.
Dubiel W, Ferrell K, Rechsteiner M (1993). "Peptide sequencing identifies MSS1, a modulator of HIV Tat-mediated transactivation, as subunit 7 of the 26 S protease". FEBS Lett.323 (3): 276–8. doi:10.1016/0014-5793(93)81356-5. PMID8500623.
DeMartino GN, Proske RJ, Moomaw CR, et al. (1996). "Identification, purification, and characterization of a PA700-dependent activator of the proteasome". J. Biol. Chem.271 (6): 3112–8. doi:10.1074/jbc.271.6.3112. PMID8621709.
Seeger M, Ferrell K, Frank R, Dubiel W (1997). "HIV-1 tat inhibits the 20 S proteasome and its 11 S regulator-mediated activation". J. Biol. Chem.272 (13): 8145–8. doi:10.1074/jbc.272.13.8145. PMID9079628.
Tanaka T, Nakamura T, Takagi H, Sato M (1997). "Molecular cloning and characterization of a novel TBP-1 interacting protein (TBPIP):enhancement of TBP-1 action on Tat by TBPIP". Biochem. Biophys. Res. Commun.239 (1): 176–81. doi:10.1006/bbrc.1997.7447. PMID9345291.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID9373149.
Nakamura T, Tanaka T, Takagi H, Sato M (1998). "Cloning and heterogeneous in vivo expression of Tat binding protein-1 (TBP-1) in the mouse". Biochim. Biophys. Acta1399 (1): 93–100. doi:10.1016/s0167-4781(98)00105-5. PMID9714759.
Tanahashi N, Murakami Y, Minami Y, et al. (2000). "Hybrid proteasomes. Induction by interferon-gamma and contribution to ATP-dependent proteolysis". J. Biol. Chem.275 (19): 14336–45. doi:10.1074/jbc.275.19.14336. PMID10799514.