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Proteasome (prosome, macropain) 26S subunit, ATPase, 4
Protein PSMC4 PDB 2dvw.png
PDB rendering based on 2dvw.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PSMC4 ; MIP224; RPT3; S6; TBP-7; TBP7
External IDs OMIM602707 MGI1346093 HomoloGene4744 GeneCards: PSMC4 Gene
Species Human Mouse
Entrez 5704 23996
Ensembl ENSG00000013275 ENSMUSG00000030603
UniProt P43686 P54775
RefSeq (mRNA) NM_006503 NM_011874
RefSeq (protein) NP_006494 NP_036004
Location (UCSC) Chr 19:
40.48 – 40.49 Mb
Chr 7:
28.04 – 28.05 Mb
PubMed search [1] [2]

26S protease regulatory subunit 6B is an enzyme that in humans is encoded by the PSMC4 gene.[1][2][3]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. This subunit has been shown to interact with an orphan member of the nuclear hormone receptor superfamily highly expressed in liver, and with gankyrin, a liver oncoprotein. Two transcript variants encoding different isoforms have been identified.[3]


PSMC4 has been shown to interact with PSMD13,[4] PSMD10,[4][5][6] PSMC2[4][7] and PSMC5.[4][5]


  1. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH, Tanaka K (Mar 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  2. ^ Choi HS, Seol W, Moore DD (May 1996). "A component of the 26S proteasome binds on orphan member of the nuclear hormone receptor superfamily". J Steroid Biochem Mol Biol 56 (1–6 Spec No): 23–30. doi:10.1016/0960-0760(95)00220-0. PMID 8603043. 
  3. ^ a b "Entrez Gene: PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4". 
  4. ^ a b c d Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ a b Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Dawson, Simon; Apcher Sebastien; Mee Maureen; Higashitsuji Hiroaki; Baker Rohan; Uhle Stefan; Dubiel Wolfgang; Fujita Jun; Mayer R John (Mar 2002). "Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome". J. Biol. Chem. (United States) 277 (13): 10893–902. doi:10.1074/jbc.M107313200. ISSN 0021-9258. PMID 11779854. 
  7. ^ Hartmann-Petersen, R; Tanaka K; Hendil K B (Feb 2001). "Quaternary structure of the ATPase complex of human 26S proteasomes determined by chemical cross-linking". Arch. Biochem. Biophys. (United States) 386 (1): 89–94. doi:10.1006/abbi.2000.2178. ISSN 0003-9861. PMID 11361004. 

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