From Wikipedia, the free encyclopedia
Jump to: navigation, search
Proteasome (prosome, macropain) 26S subunit, ATPase, 5
Protein PSMC5 PDB 2KRK.png
Rendering based on PDB 2KRK.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PSMC5 ; S8; SUG-1; SUG1; TBP10; TRIP1; p45; p45/SUG
External IDs OMIM601681 MGI105047 HomoloGene2098 GeneCards: PSMC5 Gene
RNA expression pattern
PBB GE PSMC5 209503 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5705 19184
Ensembl ENSG00000087191 ENSMUSG00000020708
UniProt P62195 P62196
RefSeq (mRNA) NM_001199163 NM_008950
RefSeq (protein) NP_001186092 NP_032976
Location (UCSC) Chr 17:
61.9 – 61.91 Mb
Chr 11:
106.26 – 106.26 Mb
PubMed search [1] [2]

26S protease regulatory subunit 8 is an enzyme that in humans is encoded by the PSMC5 gene.[1][2][3]


The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. In addition to participation in proteasome functions, this subunit may participate in transcriptional regulation since it has been shown to interact with the thyroid hormone receptor and retinoid X receptor-alpha.[3]


PSMC5 has been shown to interact with:


  1. ^ Tanahashi N, Suzuki M, Fujiwara T, Takahashi E, Shimbara N, Chung CH et al. (March 1998). "Chromosomal localization and immunological analysis of a family of human 26S proteasomal ATPases". Biochem Biophys Res Commun 243 (1): 229–32. doi:10.1006/bbrc.1997.7892. PMID 9473509. 
  2. ^ Hoyle J, Tan KH, Fisher EM (March 1997). "Localization of genes encoding two human one-domain members of the AAA family: PSMC5 (the thyroid hormone receptor-interacting protein, TRIP1) and PSMC3 (the Tat-binding protein, TBP1)". Hum Genet 99 (2): 285–8. doi:10.1007/s004390050356. PMID 9048938. 
  3. ^ a b "Entrez Gene: PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5". 
  4. ^ Ishizuka T, Satoh T, Monden T, Shibusawa N, Hashida T, Yamada M et al. (August 2001). "Human immunodeficiency virus type 1 Tat binding protein-1 is a transcriptional coactivator specific for TR". Mol. Endocrinol. 15 (8): 1329–43. doi:10.1210/mend.15.8.0680. PMID 11463857. 
  5. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  7. ^ Su K, Yang X, Roos MD, Paterson AJ, Kudlow JE (June 2000). "Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1". Biochem. J. 348. 348 Pt 2: 281–9. doi:10.1042/0264-6021:3480281. PMC 1221064. PMID 10816420. 
  8. ^ Wang YT, Chuang JY, Shen MR, Yang WB, Chang WC, Hung JJ (July 2008). "Sumoylation of specificity protein 1 augments its degradation by changing the localization and increasing the specificity protein 1 proteolytic process". J. Mol. Biol. 380 (5): 869–85. doi:10.1016/j.jmb.2008.05.043. PMID 18572193. 
  9. ^ Weeda G, Rossignol M, Fraser RA, Winkler GS, Vermeulen W, van 't Veer LJ et al. (June 1997). "The XPB subunit of repair/transcription factor TFIIH directly interacts with SUG1, a subunit of the 26S proteasome and putative transcription factor". Nucleic Acids Res. 25 (12): 2274–83. doi:10.1093/nar/25.12.2274. PMC 146752. PMID 9173976. 

Further reading[edit]