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Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Protein PSMD10 PDB 1qym.png
PDB rendering based on 1qym.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PSMD10 ; dJ889N15.2; p28; p28(GANK)
External IDs OMIM300880 MGI1858898 HomoloGene94517 GeneCards: PSMD10 Gene
RNA expression pattern
PBB GE PSMD10 219485 s at tn.png
PBB GE PSMD10 gnf1h05583 at tn.png
PBB GE PSMD10 gnf1h05584 x at tn.png
More reference expression data
Species Human Mouse
Entrez 5716 53380
Ensembl ENSG00000101843 ENSMUSG00000031429
UniProt O75832 Q9Z2X2
RefSeq (mRNA) NM_002814 NM_001164177
RefSeq (protein) NP_002805 NP_001157649
Location (UCSC) Chr X:
107.33 – 107.33 Mb
Chr X:
140.95 – 140.96 Mb
PubMed search [1] [2]

26S proteasome non-ATPase regulatory subunit 10 is an enzyme that in humans is encoded by the PSMD10 gene.[1]

The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[2]


PSMD10 has been shown to interact with PAAF1,[3] Mdm2[4] and PSMC4.[3][5][6]


  1. ^ Hori T, Kato S, Saeki M, DeMartino GN, Slaughter CA, Takeuchi J, Toh-e A, Tanaka K (Oct 1998). "cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome". Gene 216 (1): 113–22. doi:10.1016/S0378-1119(98)00309-6. PMID 9714768. 
  2. ^ "Entrez Gene: PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10". 
  3. ^ a b Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  4. ^ Qiu, W; Wu J, Walsh E M, Zhang Y, Chen C-Y, Fujita J, Xiao Z-X J (Jul 2008). "Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells". Oncogene (England) 27 (29): 4034–43. doi:10.1038/onc.2008.43. PMID 18332869. 
  5. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  6. ^ Dawson, Simon; Apcher Sebastien; Mee Maureen; Higashitsuji Hiroaki; Baker Rohan; Uhle Stefan; Dubiel Wolfgang; Fujita Jun; Mayer R John (Mar 2002). "Gankyrin is an ankyrin-repeat oncoprotein that interacts with CDK4 kinase and the S6 ATPase of the 26 S proteasome". J. Biol. Chem. (United States) 277 (13): 10893–902. doi:10.1074/jbc.M107313200. ISSN 0021-9258. PMID 11779854. 

Further reading[edit]