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Proline-serine-threonine phosphatase interacting protein 1
Protein PSTPIP1 PDB 2dil.png
PDB rendering based on 2dil.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606347 MGI1321396 HomoloGene37867 GeneCards: PSTPIP1 Gene
RNA expression pattern
PBB GE PSTPIP1 211178 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9051 19200
Ensembl ENSG00000140368 ENSMUSG00000032322
UniProt O43586 P97814
RefSeq (mRNA) NM_003978 NM_011193
RefSeq (protein) NP_003969 NP_035323
Location (UCSC) Chr 15:
77.29 – 77.33 Mb
Chr 9:
56.09 – 56.13 Mb
PubMed search [1] [2]

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.[1][2]


PSTPIP1 has been shown to interact with:

See also[edit]


  1. ^ a b Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R et al. (February 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J. 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189.  Check date values in: |year= / |date= mismatch (help)
  2. ^ "Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1". 
  3. ^ Cong F, Spencer S, Côté JF, Wu Y, Tremblay ML, Lasky LA et al. (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell 6 (6): 1413–23. doi:10.1016/s1097-2765(00)00138-6. PMID 11163214. 
  4. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ Dowbenko D, Spencer S, Quan C, Lasky LA (January 1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. 273 (2): 989–96. doi:10.1074/jbc.273.2.989. PMID 9422760. 
  6. ^ Spencer S, Dowbenko D, Cheng J, Li W, Brush J, Utzig S et al. (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. 138 (4): 845–60. doi:10.1083/jcb.138.4.845. PMC 2138048. PMID 9265651. 
  7. ^ Wu Y, Spencer SD, Lasky LA (March 1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. 273 (10): 5765–70. doi:10.1074/jbc.273.10.5765. PMID 9488710. 

Further reading[edit]