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Proline-serine-threonine phosphatase interacting protein 1
Protein PSTPIP1 PDB 2dil.png
PDB rendering based on 2dil.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606347 MGI1321396 HomoloGene37867 GeneCards: PSTPIP1 Gene
RNA expression pattern
PBB GE PSTPIP1 211178 s at tn.png
More reference expression data
Species Human Mouse
Entrez 9051 19200
Ensembl ENSG00000140368 ENSMUSG00000032322
UniProt O43586 P97814
RefSeq (mRNA) NM_003978 NM_011193
RefSeq (protein) NP_003969 NP_035323
Location (UCSC) Chr 15:
77.29 – 77.33 Mb
Chr 9:
56.09 – 56.13 Mb
PubMed search [1] [2]

Proline-serine-threonine phosphatase-interacting protein 1 is an enzyme that in humans is encoded by the PSTPIP1 gene.[1][2]


PSTPIP1 has been shown to interact with PTPN12,[3] PTPN18,[4] BZW1,[5] Abl gene,[6] Wiskott-Aldrich syndrome protein[7] and CD2.[1]

See also[edit]


  1. ^ a b Li J, Nishizawa K, An W, Hussey RE, Lialios FE, Salgia R, Sunder-Plassmann R, Reinherz EL (February 1999). "A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion". EMBO J 17 (24): 7320–36. doi:10.1093/emboj/17.24.7320. PMC 1171078. PMID 9857189. 
  2. ^ "Entrez Gene: PSTPIP1 proline-serine-threonine phosphatase interacting protein 1". 
  3. ^ Dowbenko, D; Spencer S; Quan C; Lasky L A (January 1998). "Identification of a novel polyproline recognition site in the cytoskeletal associated protein, proline serine threonine phosphatase interacting protein". J. Biol. Chem. (UNITED STATES) 273 (2): 989–96. doi:10.1074/jbc.273.2.989. ISSN 0021-9258. PMID 9422760. 
  4. ^ Spencer, S; Dowbenko D; Cheng J; Li W; Brush J; Utzig S; Simanis V; Lasky L A (August 1997). "PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase". J. Cell Biol. (UNITED STATES) 138 (4): 845–60. doi:10.1083/jcb.138.4.845. ISSN 0021-9525. PMC 2138048. PMID 9265651. 
  5. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  6. ^ Cong, F; Spencer S; Côté J F; Wu Y; Tremblay M L; Lasky L A; Goff S P (December 2000). "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl dephosphorylation". Mol. Cell (United States) 6 (6): 1413–23. doi:10.1016/S1097-2765(00)00138-6. ISSN 1097-2765. PMID 11163214. 
  7. ^ Wu, Y; Spencer S D; Lasky L A (March 1998). "Tyrosine phosphorylation regulates the SH3-mediated binding of the Wiskott-Aldrich syndrome protein to PSTPIP, a cytoskeletal-associated protein". J. Biol. Chem. (UNITED STATES) 273 (10): 5765–70. doi:10.1074/jbc.273.10.5765. ISSN 0021-9258. PMID 9488710. 

Further reading[edit]