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Protein tyrosine phosphatase type IVA, member 1
Protein PTP4A1 PDB 1rxd.png
PDB rendering based on 1rxd.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTP4A1 ; HH72; PRL-1; PRL1; PTP(CAAX1); PTPCAAX1
External IDs OMIM601585 MGI1277096 HomoloGene2587 ChEMBL: 1075169 GeneCards: PTP4A1 Gene
EC number
RNA expression pattern
PBB GE PTP4A1 200733 s at tn.png
PBB GE PTP4A1 200730 s at tn.png
PBB GE PTP4A1 200731 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7803 19243
Ensembl ENSG00000112245 ENSMUSG00000026064
UniProt Q93096 Q63739
RefSeq (mRNA) NM_003463 NM_011200
RefSeq (protein) NP_003454 NP_035330
Location (UCSC) Chr 6:
64.23 – 64.29 Mb
Chr 1:
30.94 – 30.95 Mb
PubMed search [1] [2]

Protein tyrosine phosphatase type IVA 1 is an enzyme that in humans is encoded by the PTP4A1 gene.[1][2]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.[2]


PTP4A1 has been shown to interact with ATF7.[3]


  1. ^ Peng Y, Genin A, Spinner NB, Diamond RH, Taub R (Aug 1998). "The gene encoding human nuclear protein tyrosine phosphatase, PRL-1. Cloning, chromosomal localization, and identification of an intron enhancer". J Biol Chem 273 (27): 17286–95. doi:10.1074/jbc.273.27.17286. PMID 9642300. 
  2. ^ a b "Entrez Gene: PTP4A1 protein tyrosine phosphatase type IVA, member 1". 
  3. ^ Peters, C S; Liang X; Li S; Kannan S; Peng Y; Taub R; Diamond R H (Apr 2001). "ATF-7, a novel bZIP protein, interacts with the PRL-1 protein-tyrosine phosphatase". J. Biol. Chem. (United States) 276 (17): 13718–26. doi:10.1074/jbc.M011562200. ISSN 0021-9258. PMID 11278933. 

Further reading[edit]