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Protein tyrosine phosphatase type IVA, member 3
Protein PTP4A3 PDB 1r6h.png
PDB rendering based on 1r6h.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTP4A3 ; PRL-3; PRL-R; PRL3
External IDs OMIM606449 MGI1277098 HomoloGene22500 ChEMBL: 4162 GeneCards: PTP4A3 Gene
EC number
RNA expression pattern
PBB GE PTP4A3 209695 at tn.png
PBB GE PTP4A3 206574 s at tn.png
PBB GE PTP4A3 214223 at tn.png
More reference expression data
Species Human Mouse
Entrez 11156 19245
Ensembl ENSG00000184489 ENSMUSG00000059895
UniProt O75365 Q9D658
RefSeq (mRNA) NM_007079 NM_001166388
RefSeq (protein) NP_009010 NP_001159860
Location (UCSC) Chr 8:
142.4 – 142.44 Mb
Chr 15:
73.72 – 73.76 Mb
PubMed search [1] [2]

Protein tyrosine phosphatase type IVA 3 is an enzyme that in humans is encoded by the PTP4A3 gene.[1]

The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs). PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This class of PTPs contain a PTP domain and a characteristic C-terminal prenylation motif. Studies of this class of PTPs in mice demonstrated that they were prenylated proteins in vivo, which suggested their association with cell plasma membrane. Overexpression of this gene in mammalian cells was reported to inhibit angiotensin-II induced cell calcium mobilization and promote cell growth. Two alternatively spliced variants exist.[1]


Further reading[edit]