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Protein tyrosine phosphatase, non-receptor type 18 (brain-derived)
Protein PTPN18 PDB 2oc3.png
PDB rendering based on 2oc3.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTPN18 ; BDP1; PTP-HSCF
External IDs OMIM606587 MGI108410 HomoloGene74971 GeneCards: PTPN18 Gene
EC number
RNA expression pattern
PBB GE PTPN18 203555 at tn.png
PBB GE PTPN18 213521 at tn.png
More reference expression data
Species Human Mouse
Entrez 26469 19253
Ensembl ENSG00000072135 ENSMUSG00000026126
UniProt Q99952 Q61152
RefSeq (mRNA) NM_001142370 NM_011206
RefSeq (protein) NP_001135842 NP_035336
Location (UCSC) Chr 2:
131.11 – 131.13 Mb
Chr 1:
34.46 – 34.47 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.[2]


PTPN18 has been shown to interact with PSTPIP1.[3]


  1. ^ Kim YW, Wang H, Sures I, Lammers R, Martell KJ, Ullrich A (January 1997). "Characterization of the PEST family protein tyrosine phosphatase BDP1". Oncogene 13 (10): 2275–9. PMID 8950995. 
  2. ^ a b "Entrez Gene: PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived)". 
  3. ^ Spencer, S; Dowbenko D; Cheng J; Li W; Brush J; Utzig S; Simanis V; Lasky L A (August 1997). "PSTPIP: A Tyrosine Phosphorylated Cleavage Furrow–associated Protein that Is a Substrate for a PEST Tyrosine Phosphatase". J. Cell Biol. (UNITED STATES) 138 (4): 845–60. doi:10.1083/jcb.138.4.845. ISSN 0021-9525. PMC 2138048. PMID 9265651. 

Further reading[edit]