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Protein tyrosine phosphatase, non-receptor type 2
Protein PTPN2 PDB 1l8k.png
PDB rendering based on 1l8k.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176887 MGI97806 HomoloGene7497 ChEMBL: 3807 GeneCards: PTPN2 Gene
EC number
Species Human Mouse
Entrez 5771 19255
Ensembl ENSG00000175354 ENSMUSG00000024539
UniProt P17706 Q06180
RefSeq (mRNA) NM_001207013 NM_001127177
RefSeq (protein) NP_001193942 NP_001120649
Location (UCSC) Chr 18:
12.79 – 12.93 Mb
Chr 18:
67.67 – 67.72 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been described. The different C-termini are thought to determine the substrate specificity, as well as the cellular localization of the isoforms. Two highly related but distinctly processed pseudogenes that localize to distinct chromosomes have been reported.[2]


  1. ^ Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990). "Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B". Proc Natl Acad Sci U S A 87 (13): 5148–52. doi:10.1073/pnas.87.13.5148. PMC 54279. PMID 2164224. 
  2. ^ a b "Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2". 

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