Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.
^Jui, H Y; Tseng R J, Wen X, Fang H I, Huang L M, Chen K Y, Kung H J, Ann D K, Shih H M (Dec 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. (UNITED STATES) 275 (52): 41124–32. doi:10.1074/jbc.M007772200. ISSN0021-9258. PMID11013262.Cite uses deprecated parameters (help)
^Dorner, C; Ciossek T, Müller S, Møller P H, Ullrich A, Lammers R (Aug 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J. Biol. Chem. (UNITED STATES) 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. ISSN0021-9258. PMID9685376.Cite uses deprecated parameters (help)
Zeitlin AA, Heward JM, Brand OJ, et al. (2007). "Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.". Clin. Endocrinol. (Oxf)65 (3): 380–4. doi:10.1111/j.1365-2265.2006.02608.x. PMID16918960.
Jui HY, Tseng RJ, Wen X, et al. (2001). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases.". J. Biol. Chem.275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID11013262.
Dorner C, Ciossek T, Müller S, et al. (1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum.". J. Biol. Chem.273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID9685376.
Higashitsuji H, Arii S, Furutani M, et al. (1995). "Enhanced expression of multiple protein tyrosine phosphatases in the regenerating mouse liver: isolation of PTP-RL10, a novel cytoplasmic-type phosphatase with sequence homology to cytoskeletal protein 4.1.". Oncogene10 (2): 407–14. PMID7838537.