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Protein tyrosine phosphatase, non-receptor type 21
Symbols PTPN21 ; PTPD1; PTPRL10
External IDs OMIM603271 MGI1344406 HomoloGene5110 ChEMBL: 4060 GeneCards: PTPN21 Gene
EC number
RNA expression pattern
PBB GE PTPN21 1320 at tn.png
PBB GE PTPN21 40524 at tn.png
PBB GE PTPN21 205438 at tn.png
More reference expression data
Species Human Mouse
Entrez 11099 24000
Ensembl ENSG00000070778 ENSMUSG00000021009
UniProt Q16825 E9PZ70
RefSeq (mRNA) NM_007039 NM_001146199
RefSeq (protein) NP_008970 NP_001139671
Location (UCSC) Chr 14:
88.93 – 89.02 Mb
Chr 12:
98.68 – 98.74 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 21 is an enzyme that in humans is encoded by the PTPN21 gene.[1][2]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain, similar to cytoskeletal- associated proteins including band 4.1, ezrin, merlin, and radixin. This PTP was shown to specially interact with BMX/ETK, a member of Tec tyrosine kinase family characterized by a multimodular structures including PH, SH3, and SH2 domains. The interaction of this PTP with BMX kinase was found to increase the activation of STAT3, but not STAT2 kinase. Studies of the similar gene in mice suggested the possible roles of this PTP in liver regeneration and spermatogenesis.[2]


PTPN21 has been shown to interact with BMX[3] and KIF1C.[4]


  1. ^ Møller NP, Møller KB, Lammers R, Kharitonenkov A, Sures I, Ullrich A (Sep 1994). "Src kinase associates with a member of a distinct subfamily of protein-tyrosine phosphatases containing an ezrin-like domain". Proc Natl Acad Sci USA 91 (16): 7477–81. doi:10.1073/pnas.91.16.7477. PMC 44424. PMID 7519780. 
  2. ^ a b "Entrez Gene: PTPN21 protein tyrosine phosphatase, non-receptor type 21". 
  3. ^ Jui HY, Tseng RJ, Wen X, Fang HI, Huang LM, Chen KY et al. (Dec 2000). "Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases". J. Biol. Chem. 275 (52): 41124–32. doi:10.1074/jbc.M007772200. PMID 11013262. 
  4. ^ Dorner C, Ciossek T, Müller S, Møller PH, Ullrich A, Lammers R (Aug 1998). "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum". J. Biol. Chem. 273 (32): 20267–75. doi:10.1074/jbc.273.32.20267. PMID 9685376. 

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