Tyrosine-protein phosphatase non-receptor type 4 is an enzyme that in humans is encoded by the PTPN4gene.
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation.
Hironaka K, Umemori H, Tezuka T et al. (2000). "The protein-tyrosine phosphatase PTPMEG interacts with glutamate receptor delta 2 and epsilon subunits". J. Biol. Chem.275 (21): 16167–73. doi:10.1074/jbc.M909302199. PMID10748123.
Park KW, Lee EJ, Lee S et al. (2001). "Molecular cloning and characterization of a protein tyrosine phosphatase enriched in testis, a putative murine homologue of human PTPMEG". Gene257 (1): 45–55. doi:10.1016/S0378-1119(00)00351-6. PMID11054567.