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Protein tyrosine phosphatase, non-receptor type 9
Protein PTPN9 PDB 2pa5.png
PDB rendering based on 2pa5.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTPN9 ; MEG2; PTPMEG2
External IDs OMIM600768 MGI1928376 HomoloGene2121 ChEMBL: 6117 GeneCards: PTPN9 Gene
EC number
RNA expression pattern
PBB GE PTPN9 202958 at tn.png
More reference expression data
Species Human Mouse
Entrez 5780 56294
Ensembl ENSG00000169410 ENSMUSG00000032290
UniProt P43378 O35239
RefSeq (mRNA) NM_002833 NM_019651
RefSeq (protein) NP_002824 NP_062625
Location (UCSC) Chr 15:
75.46 – 75.58 Mb
Chr 9:
56.99 – 57.06 Mb
PubMed search [1] [2]

Tyrosine-protein phosphatase non-receptor type 9 is an enzyme that in humans is encoded by the PTPN9 gene.[1][2]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal domain that shares a significant similarity with yeast SEC14, which is a protein that has phosphatidylinositol transfer activity and is required for protein secretion through the Golgi complex in yeast. This PTP was found to be activated by poly-phosphoinositide, and is thought to be involved in signaling events regulating phagocytosis.[2]


Further reading[edit]