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Protein tyrosine phosphatase, receptor type, A
Protein PTPRA PDB 1p15.png
PDB rendering based on 1p15.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176884 MGI97808 HomoloGene20621 IUPHAR: 1850 ChEMBL: 3918 GeneCards: PTPRA Gene
EC number
Species Human Mouse
Entrez 5786 19262
Ensembl ENSG00000132670 ENSMUSG00000027303
UniProt P18433 P18052
RefSeq (mRNA) NM_002836 NM_001163688
RefSeq (protein) NP_002827 NP_001157160
Location (UCSC) Chr 20:
2.84 – 3.02 Mb
Chr 2:
130.45 – 130.55 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase alpha is an enzyme that in humans is encoded by the PTPRA gene.[1][2][3]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.[3]


PTPRA has been shown to interact with Grb2[4][5][6] and KCNA2.[7]


  1. ^ Jirik FR, Janzen NM, Melhado IG, Harder KW (December 1990). "Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase". FEBS Lett 273 (1–2): 239–42. doi:10.1016/0014-5793(90)81094-5. PMID 2172030. 
  2. ^ Kaplan R, Morse B, Huebner K, Croce C, Howk R, Ravera M et al. (October 1990). "Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain". Proc Natl Acad Sci U S A 87 (18): 7000–4. doi:10.1073/pnas.87.18.7000. PMC 54670. PMID 2169617. 
  3. ^ a b "Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A". 
  4. ^ den Hertog J, Hunter T (June 1996). "Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains". EMBO J. 15 (12): 3016–27. PMC 450243. PMID 8670803. 
  5. ^ den Hertog J, Tracy S, Hunter T (July 1994). "Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo". EMBO J. 13 (13): 3020–32. PMC 395191. PMID 7518772. 
  6. ^ Zheng XM, Resnick RJ, Shalloway D (June 2002). "Mitotic activation of protein-tyrosine phosphatase alpha and regulation of its Src-mediated transforming activity by its sites of protein kinase C phosphorylation". J. Biol. Chem. 277 (24): 21922–9. doi:10.1074/jbc.M201394200. PMID 11923305. 
  7. ^ Tsai W, Morielli AD, Cachero TG, Peralta EG (January 1999). "Receptor protein tyrosine phosphatase alpha participates in the m1 muscarinic acetylcholine receptor-dependent regulation of Kv1.2 channel activity". EMBO J. 18 (1): 109–18. doi:10.1093/emboj/18.1.109. PMC 1171107. PMID 9878055. 

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