PTPRD

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Protein tyrosine phosphatase, receptor type, D
Protein PTPRD PDB 1lar.png
PDB rendering based on 1lar.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PTPRD ; HPTP; HPTPD; HPTPDELTA; PTPD; RPTPDELTA
External IDs OMIM601598 HomoloGene88669 GeneCards: PTPRD Gene
EC number 3.1.3.48
RNA expression pattern
PBB GE PTPRD 205712 at tn.png
PBB GE PTPRD 213362 at tn.png
PBB GE PTPRD 214043 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 5789 n/a
Ensembl ENSG00000153707 n/a
UniProt P23468 n/a
RefSeq (mRNA) NM_001040712 n/a
RefSeq (protein) NP_001035802 n/a
Location (UCSC) Chr 9:
8.31 – 10.61 Mb
n/a
PubMed search [1] n/a

Receptor-type tyrosine-protein phosphatase delta is an enzyme that in humans is encoded by the PTPRD gene.[1][2][3]

Function[edit]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, thus represents a receptor-type PTP. The extracellular region of this protein is composed of three Ig-like and eight fibronectin type III-like domains. Studies of the similar genes in chick and fly suggest the role of this PTP is in promoting neurite growth, and regulating neurons axon guidance. Multiple tissue specific alternatively spliced transcript variants of this gene have been reported.[3]

Clinical significance[edit]

Mutations in the PTPRD gene are associated with autism,[4] and breast cancer.[5]

Interactions[edit]

PTPRD has been shown to interact with PTPRS[6] and liprin-alpha-1.[7]

References[edit]

  1. ^ Pulido R, Krueger NX, Serra-Pages C, Saito H, Streuli M (Apr 1995). "Molecular characterization of the human transmembrane protein-tyrosine phosphatase delta. Evidence for tissue-specific expression of alternative human transmembrane protein-tyrosine phosphatase delta isoforms". J Biol Chem 270 (12): 6722–8. doi:10.1074/jbc.270.12.6722. PMID 7896816. 
  2. ^ Mizuno K, Hasegawa K, Katagiri T, Ogimoto M, Ichikawa T, Yakura H (Sep 1993). "MPTP delta, a putative murine homolog of HPTP delta, is expressed in specialized regions of the brain and in the B-cell lineage". Mol Cell Biol 13 (9): 5513–23. PMC 360267. PMID 8355697. 
  3. ^ a b "Entrez Gene: PTPRD protein tyrosine phosphatase, receptor type, D". 
  4. ^ Lei N, et al. (2010). "Autism Is Associated with Inherited Deletions in PTPRD and NCAM2". PAS 2010; Abstract 2320.1. Pediatric Academic Societies. 
  5. ^ The Cancer Genome Atlas Network (2012). "Comprehensive molecular portraits of human breast tumours". Nature (Nature Publishing Group) 490 (7418): 61–70. doi:10.1038/nature11412. PMC 3465532. PMID 23000897. Retrieved 24 September 2012. 
  6. ^ Wallace, M J; Fladd C; Batt J; Rotin D (May 1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. (UNITED STATES) 18 (5): 2608–16. ISSN 0270-7306. PMC 110640. PMID 9566880. 
  7. ^ Pulido, R; Serra-Pagès C; Tang M; Streuli M (Dec 1995). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. ISSN 0027-8424. PMC 40467. PMID 8524829. 

Further reading[edit]