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Protein tyrosine phosphatase, receptor type, G
Protein PTPRG PDB 2h4v.png
PDB rendering based on 2h4v.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM176886 MGI97814 HomoloGene2129 ChEMBL: 4905 GeneCards: PTPRG Gene
EC number
Species Human Mouse
Entrez 5793 19270
Ensembl ENSG00000144724 ENSMUSG00000021745
UniProt P23470 Q05909
RefSeq (mRNA) NM_002841 NM_008981
RefSeq (protein) NP_002832 NP_033007
Location (UCSC) Chr 3:
61.55 – 62.28 Mb
Chr 14:
11.55 – 12.24 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.[1][2]

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this PTP contains a carbonic anhydrase-like (CAH) domain, which is also found in the extracellular region of PTPRBETA/ZETA. This gene is located in a chromosomal region that is frequently deleted in renal cell carcinoma and lung carcinoma, thus is thought to be a candidate tumor suppressor gene.[2]


  1. ^ LaForgia S, Morse B, Levy J, Barnea G, Cannizzaro LA, Li F, Nowell PC, Boghosian-Sell L, Glick J, Weston A, et al. (Jul 1991). "Receptor protein-tyrosine phosphatase gamma is a candidate tumor suppressor gene at human chromosome region 3p21". Proc Natl Acad Sci U S A 88 (11): 5036–40. doi:10.1073/pnas.88.11.5036. PMC 51802. PMID 1711217. 
  2. ^ a b "Entrez Gene: PTPRG protein tyrosine phosphatase, receptor type, G". 

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