The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region containing five fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic catalytic domain, and thus represents a receptor-type PTP. This PTP is present in all hematopoietic lineages, and was shown to negatively regulate T cell receptor signaling possibly through interfering with the phosphorylation of Phospholipase C Gamma 1 (PLCG1) and Linker for Activation of T Cells (LAT). This PTP was also found to dephosphorylate PDGF beta receptor, and may be involved in UV-induced signal transduction.
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Ruivenkamp CA, van Wezel T, Zanon C, Stassen AP, Vlcek C, Csikós T et al. (2002). "Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers". Nat. Genet.31 (3): 295–300. doi:10.1038/ng903. PMID12089527.
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Dong HY, Shahsafaei A, Dorfman DM (2003). "CD148 and CD27 are expressed in B cell lymphomas derived from both memory and naïve B cells". Leuk. Lymphoma43 (9): 1855–8. doi:10.1080/1042819021000006385. PMID12685844.
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Massa A, Barbieri F, Aiello C, Arena S, Pattarozzi A, Pirani P et al. (2004). "The expression of the phosphotyrosine phosphatase DEP-1/PTPeta dictates the responsivity of glioma cells to somatostatin inhibition of cell proliferation". J. Biol. Chem.279 (28): 29004–12. doi:10.1074/jbc.M403573200. PMID15123617.