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Protein tyrosine phosphatase, receptor type, S
Protein PTPRS PDB 2fh7.png
PDB rendering based on 2fh7.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM601576 MGI97815 HomoloGene20626 IUPHAR: 1866 GeneCards: PTPRS Gene
EC number
RNA expression pattern
PBB GE PTPRS 210823 s at tn.png
More reference expression data
Species Human Mouse
Entrez 5802 19280
Ensembl ENSG00000105426 ENSMUSG00000013236
UniProt Q13332 B0V2N1
RefSeq (mRNA) NM_002850 NM_001252453
RefSeq (protein) NP_002841 NP_001239382
Location (UCSC) Chr 19:
5.16 – 5.34 Mb
Chr 17:
56.41 – 56.48 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase S, also known as R-PTP-S, R-PTP-sigma, or PTPσ, is an enzyme that in humans is encoded by the PTPRS gene.[1][2][3]


The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.[3]

Clinical significance[edit]

A PTPRS protein mimetic may improve muscular and bladder control in rats with spinal cord injuries.[4][5]


PTPRS has been shown to interact with:


  1. ^ Wagner J, Gordon LA, Heng HH, Tremblay ML, Olsen AS (Mar 1997). "Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3". Genomics 38 (1): 76–8. doi:10.1006/geno.1996.0594. PMID 8954782. 
  2. ^ a b Pulido R, Serra-Pagès C, Tang M, Streuli M (Jan 1996). "The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1". Proc Natl Acad Sci U S A 92 (25): 11686–90. doi:10.1073/pnas.92.25.11686. PMC 40467. PMID 8524829. 
  3. ^ a b "Entrez Gene: PTPRS protein tyrosine phosphatase, receptor type, S". 
  4. ^ a b Lang BT, Cregg JM, DePaul MA, Tran AP, Xu K, Dyck SM et al. (2014). "Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury". Nature. doi:10.1038/nature13974. PMID 25470046. 
  5. ^ Maggie Fox (3 December 2014). "'Unprecedented': Drug May Help Heal Damaged Spine". NBC. Retrieved December 8, 2014. 
  6. ^ Wallace MJ, Fladd C, Batt J, Rotin D (May 1998). "The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma". Mol. Cell. Biol. 18 (5): 2608–16. PMC 110640. PMID 9566880. 
  7. ^ Serra-Pagès C, Medley QG, Tang M, Hart A, Streuli M (Jun 1998). "Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins". J. Biol. Chem. 273 (25): 15611–20. doi:10.1074/jbc.273.25.15611. PMID 9624153. 

Further reading[edit]