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Protein tyrosine phosphatase, receptor-type, Z polypeptide 1
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PTPRZ1 ; HPTPZ; HPTPzeta; PTP-ZETA; PTP18; PTPRZ; PTPZ; R-PTP-zeta-2; RPTPB; RPTPbeta; phosphacan
External IDs OMIM176891 MGI97816 HomoloGene2136 IUPHAR: 1869 GeneCards: PTPRZ1 Gene
EC number
RNA expression pattern
PBB GE PTPRZ1 204469 at tn.png
More reference expression data
Species Human Mouse
Entrez 5803 19283
Ensembl ENSG00000106278 ENSMUSG00000068748
UniProt P23471 B9EKR1
RefSeq (mRNA) NM_001206838 NM_001081306
RefSeq (protein) NP_001193767 NP_001074775
Location (UCSC) Chr 7:
121.51 – 121.7 Mb
Chr 6:
22.88 – 23.05 Mb
PubMed search [1] [2]

Receptor-type tyrosine-protein phosphatase zeta also known as phosphacan is an enzyme that in humans is encoded by the PTPRZ1 gene.[1][2][3]


This gene is a member of the receptor tyrosine phosphatase family and encodes a single-pass type I membrane protein with two cytoplasmic tyrosine-protein phosphatase domains, an alpha-carbonic anhydrase domain and a fibronectin type III domain. Alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[3]

Clinical significance[edit]

Expression of this gene is induced in gastric cancer cells, in the remyelinating oligodendrocytes of multiple sclerosis lesions, and in human embryonic kidney cells under hypoxic conditions. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration.[3]


  1. ^ Ariyama T, Hasegawa K, Inazawa J, Mizuno K, Ogimoto M, Katagiri T et al. (Jun 1995). "Assignment of the human protein tyrosine phosphatase, receptor-type, zeta (PTPRZ) gene to chromosome band 7q31.3". Cytogenet Cell Genet 70 (1–2): 52–4. doi:10.1159/000133990. PMID 7736789. 
  2. ^ Levy JB, Canoll PD, Silvennoinen O, Barnea G, Morse B, Honegger AM et al. (Jun 1993). "The cloning of a receptor-type protein tyrosine phosphatase expressed in the central nervous system". J Biol Chem 268 (14): 10573–81. PMID 8387522. 
  3. ^ a b c "Entrez Gene: PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1". 

Further reading[edit]