PUM1

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Pumilio RNA-binding family member 1
Protein PUM1 PDB 1ib2.png
PDB rendering based on 1ib2.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PUM1 ; HSPUM; PUMH; PUMH1; PUML1
External IDs OMIM607204 MGI1931749 HomoloGene22830 GeneCards: PUM1 Gene
RNA expression pattern
PBB GE PUM1 201166 s at tn.png
PBB GE PUM1 201164 s at tn.png
PBB GE PUM1 201165 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9698 80912
Ensembl ENSG00000134644 ENSMUSG00000028580
UniProt Q14671 Q80U78
RefSeq (mRNA) NM_001020658 NM_001159603
RefSeq (protein) NP_001018494 NP_001153075
Location (UCSC) Chr 1:
31.4 – 31.54 Mb
Chr 4:
130.66 – 130.78 Mb
PubMed search [1] [2]

Pumilio homolog 1 is a protein that in humans is encoded by the PUM1 gene.[1]

Function[edit]

This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain composed of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3' untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.[1]

References[edit]

Further reading[edit]