PVRL3

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Poliovirus receptor-related 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PVRL3 ; CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3
External IDs OMIM607147 HomoloGene9162 GeneCards: PVRL3 Gene
RNA expression pattern
PBB GE PVRL3 213325 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25945 58998
Ensembl ENSG00000177707 ENSMUSG00000022656
UniProt Q9NQS3 Q9JLB9
RefSeq (mRNA) NM_001243286 NM_021495
RefSeq (protein) NP_001230215 NP_067470
Location (UCSC) Chr 3:
110.79 – 110.99 Mb
Chr 16:
46.39 – 46.5 Mb
PubMed search [1] [2]

Poliovirus receptor-related 3 (nectin-3), also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.[1]

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]

See also[edit]

Interactions[edit]

PVRL3 has been shown to interact with MLLT4,[2][3] PARD3,[4] and PTPmu (PTPRM).[5]

References[edit]

  1. ^ a b "Entrez Gene: PVRL3 poliovirus receptor-related 3". 
  2. ^ Satoh-Horikawa, K; Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K, Mizoguchi A, Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. (UNITED STATES) 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. ISSN 0021-9258. PMID 10744716. 
  3. ^ Reymond, N; Borg J P, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P, Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene (NETHERLANDS) 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. ISSN 0378-1119. PMID 11024295. 
  4. ^ Takekuni, Kyoji; Ikeda Wataru, Fujito Tsutomu, Morimoto Koji, Takeuchi Masakazu, Monden Morito, Takai Yoshimi (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. (United States) 278 (8): 5497–500. doi:10.1074/jbc.C200707200. ISSN 0021-9258. PMID 12515806. 
  5. ^ Sakamoto Y, Ogita H, Komura H, Takai Y (2008). "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion". J Biol Chem 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.