Poliovirus receptor-related 3

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Poliovirus receptor-related 3
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols PVRL3 ; CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3
External IDs OMIM607147 HomoloGene9162 GeneCards: PVRL3 Gene
RNA expression pattern
PBB GE PVRL3 213325 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 25945 58998
Ensembl ENSG00000177707 ENSMUSG00000022656
UniProt Q9NQS3 Q9JLB9
RefSeq (mRNA) NM_001243286 NM_021495
RefSeq (protein) NP_001230215 NP_067470
Location (UCSC) Chr 3:
110.79 – 110.99 Mb
Chr 16:
46.39 – 46.5 Mb
PubMed search [1] [2]

Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions.[1]

Function[edit]

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]

Interactions[edit]

PVRL3 has been shown to interact with:

See also[edit]

References[edit]

  1. ^ a b "Entrez Gene: PVRL3 poliovirus receptor-related 3". 
  2. ^ Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K et al. (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716. 
  3. ^ Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P et al. (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. doi:10.1016/s0378-1119(00)00316-4. PMID 11024295. 
  4. ^ Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M et al. (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806. 
  5. ^ Sakamoto Y, Ogita H, Komura H, Takai Y. "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion". J. Biol. Chem. 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016. 

Further reading[edit]

  • Satoh-Horikawa K, Nakanishi H, Takahashi K, Miyahara M, Nishimura M, Tachibana K et al. (2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. PMID 10744716. 
  • Reymond N, Borg JP, Lecocq E, Adelaide J, Campadelli-Fiume G, Dubreuil P et al. (2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. PMID 11024295. 
  • Fabre S, Reymond N, Cocchi F, Menotti L, Dubreuil P, Campadelli-Fiume G et al. (2002). "Prominent role of the Ig-like V domain in trans-interactions of nectins. Nectin3 and nectin 4 bind to the predicted C-C'-C"-D beta-strands of the nectin1 V domain". J. Biol. Chem. 277 (30): 27006–13. doi:10.1074/jbc.M203228200. PMID 12011057. 
  • Takekuni K, Ikeda W, Fujito T, Morimoto K, Takeuchi M, Monden M et al. (2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. 278 (8): 5497–500. doi:10.1074/jbc.C200707200. PMID 12515806. 
  • Mueller S, Wimmer E (2003). "Recruitment of nectin-3 to cell-cell junctions through trans-heterophilic interaction with CD155, a vitronectin and poliovirus receptor that localizes to alpha(v)beta3 integrin-containing membrane microdomains". J. Biol. Chem. 278 (33): 31251–60. doi:10.1074/jbc.M304166200. PMID 12759359. 
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  • Fujito T, Ikeda W, Kakunaga S, Minami Y, Kajita M, Sakamoto Y et al. (2005). "Inhibition of cell movement and proliferation by cell–cell contact-induced interaction of Necl-5 with nectin-3". J. Cell Biol. 171 (1): 165–73. doi:10.1083/jcb.200501090. PMC 2171219. PMID 16216929. 

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.