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Poliovirus receptor-related 3
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols PVRL3 ; CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRR3
External IDs OMIM607147 HomoloGene9162 GeneCards: PVRL3 Gene
RNA expression pattern
PBB GE PVRL3 213325 at tn.png
More reference expression data
Species Human Mouse
Entrez 25945 58998
Ensembl ENSG00000177707 ENSMUSG00000022656
UniProt Q9NQS3 Q9JLB9
RefSeq (mRNA) NM_001243286 NM_021495
RefSeq (protein) NP_001230215 NP_067470
Location (UCSC) Chr 3:
110.79 – 110.99 Mb
Chr 16:
46.39 – 46.5 Mb
PubMed search [1] [2]

Poliovirus receptor-related 3 (nectin-3), also known as PVRL3 and CD113 (Cluster of Differentiation 113), is a human gene.[1]

Nectins (e.g., PVRL1; MIM 600644) are immunoglobulin-like adhesion molecules that interact with afadin (AF6; MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin (see MIM 192090)-catenin (see MIM 116805) system in epithelial cells.[supplied by OMIM][1]

See also[edit]


PVRL3 has been shown to interact with MLLT4,[2][3] PARD3,[4] and PTPmu (PTPRM).[5]


  1. ^ a b "Entrez Gene: PVRL3 poliovirus receptor-related 3". 
  2. ^ Satoh-Horikawa, K; Nakanishi H; Takahashi K; Miyahara M; Nishimura M; Tachibana K; Mizoguchi A; Takai Y (April 2000). "Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities". J. Biol. Chem. (UNITED STATES) 275 (14): 10291–9. doi:10.1074/jbc.275.14.10291. ISSN 0021-9258. PMID 10744716. 
  3. ^ Reymond, N; Borg J P; Lecocq E; Adelaide J; Campadelli-Fiume G; Dubreuil P; Lopez M (September 2000). "Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin". Gene (NETHERLANDS) 255 (2): 347–55. doi:10.1016/S0378-1119(00)00316-4. ISSN 0378-1119. PMID 11024295. 
  4. ^ Takekuni, Kyoji; Ikeda Wataru; Fujito Tsutomu; Morimoto Koji; Takeuchi Masakazu; Monden Morito; Takai Yoshimi (February 2003). "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse". J. Biol. Chem. (United States) 278 (8): 5497–500. doi:10.1074/jbc.C200707200. ISSN 0021-9258. PMID 12515806. 
  5. ^ Sakamoto Y, Ogita H, Komura H, Takai Y (2008). "Involvement of nectin in inactivation of integrin alpha(v)beta(3) after the establishment of cell-cell adhesion". J Biol Chem 283 (1): 496–505. doi:10.1074/jbc.M704195200. PMID 17965016. 

Further reading[edit]

External links[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.