PVT1

Pvt1 oncogene (non-protein coding)
Identifiers
Symbols	PVT1; LINC00079; NCRNA00079
External IDs	OMIM: 165140 HomoloGene: 90803 GeneCards: PVT1 Gene
Gene Ontology
Orthologs
Species	Human	Mouse
Entrez	5820	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	NR_003367.1	n/a
RefSeq (protein)	XP_001129539	n/a
Location (UCSC)	n/a	n/a
PubMed search	[1]	n/a

Pvt1 oncogene (non-protein coding), also known as PVT1, is a long non-coding RNA gene. In mice, this gene was identified as a breakpoint site in chromosome 6;15 translocations. These translations are associated with murine plasmacytomas. The equivalent translocation in humans is t(2;8), which is assicoated with a rare variant of Burkitt's lymphoma. In rats, this breakpoint was shown to be a common site of proviral integration in retrovirally induced T lymphomas. Transcription of PVT1 is regulated by Myc.

Further reading

• Guan Y, Kuo WL, Stilwell JL, et al. (2007). "Amplification of PVT1 contributes to the pathophysiology of ovarian and breast cancer.". Clin. Cancer Res. 13 (19): 5745–55. doi:10.1158/1078-0432.CCR-06-2882. PMID 17908964. 
• Millis MP, Bowen D, Kingsley C, et al. (2007). "Variants in the plasmacytoma variant translocation gene (PVT1) are associated with end-stage renal disease attributed to type 1 diabetes.". Diabetes 56 (12): 3027–32. doi:10.2337/db07-0675. PMID 17881614. 
• Carramusa L, Contino F, Ferro A, et al. (2008). "The PVT-1 oncogene is a Myc protein target that is overexpressed in transformed cells.". J. Cell. Physiol. 213 (2): 511–8. doi:10.1002/jcp.21133. PMID 17503467. 
• Hanson RL, Craig DW, Millis MP, et al. (2007). "Identification of PVT1 as a candidate gene for end-stage renal disease in type 2 diabetes using a pooling-based genome-wide single nucleotide polymorphism association study.". Diabetes 56 (4): 975–83. doi:10.2337/db06-1072. PMID 17395743. 
• Oh JH, Yang JO, Hahn Y, et al. (2006). "Transcriptome analysis of human gastric cancer.". Mamm. Genome 16 (12): 942–54. doi:10.1007/s00335-005-0075-2. PMID 16341674. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Graham M, Adams JM (1987). "Chromosome 8 breakpoint far 3' of the c-myc oncogene in a Burkitt's lymphoma 2;8 variant translocation is equivalent to the murine pvt-1 locus.". EMBO J. 5 (11): 2845–51. PMC 1167233. PMID 3024964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1167233. 
• Shtivelman E, Bishop JM (1989). "The PVT gene frequently amplifies with MYC in tumor cells.". Mol. Cell. Biol. 9 (3): 1148–54. PMC 362705. PMID 2725491. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=362705. 
• Shtivelman E, Henglein B, Groitl P, et al. (1989). "Identification of a human transcription unit affected by the variant chromosomal translocations 2;8 and 8;22 of Burkitt lymphoma.". Proc. Natl. Acad. Sci. U.S.A. 86 (9): 3257–60. doi:10.1073/pnas.86.9.3257. PMC 287109. PMID 2470097. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=287109. 
• Shtivelman E, Bishop JM (1990). "Effects of translocations on transcription from PVT.". Mol. Cell. Biol. 10 (4): 1835–9. PMC 362296. PMID 2181290. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=362296.