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PYD and CARD domain containing
Protein PYCARD PDB 1ucp.png
PDB rendering based on 1ucp.
Available structures
PDB Ortholog search: PDBe, RCSB
External IDs OMIM606838 MGI1931465 HomoloGene8307 GeneCards: PYCARD Gene
RNA expression pattern
PBB GE PYCARD 221666 s at tn.png
More reference expression data
Species Human Mouse
Entrez 29108 66824
Ensembl ENSG00000103490 ENSMUSG00000030793
UniProt Q9ULZ3 Q9EPB4
RefSeq (mRNA) NM_013258 NM_023258
RefSeq (protein) NP_037390 NP_075747
Location (UCSC) Chr 16:
31.21 – 31.21 Mb
Chr 7:
127.99 – 127.99 Mb
PubMed search [1] [2]

Apoptosis-associated speck-like protein containing a CARD or ASC is a protein that in humans is encoded by the PYCARD gene.[1]

This gene encodes an adaptor protein that is composed of two protein–protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.[1]


PYCARD has been shown to interact with MEFV.[2]


  1. ^ a b "Entrez Gene: PYCARD PYD and CARD domain containing". Retrieved 18 September 2010. 
  2. ^ Richards, N; Schaner P; Diaz A; Stuckey J; Shelden E; Wadhwa A; Gumucio D L (October 2001). "Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis". J. Biol. Chem. (United States) 276 (42): 39320–9. doi:10.1074/jbc.M104730200. ISSN 0021-9258. PMID 11498534. 

Further reading[edit]