Pacific was one of the founding members of the West Coast Conference (originally the California Basketball Association and later the West Coast Athletic Conference) in 1952, but became a charter member of the Pacific Coast Athletic Association, now known as the Big West Conference, for football only in 1969 and moved the rest of its sports to the PCAA in 1971. The Tigers remained in the Big West until returning to the WCC on July 1, 2013.
The Pacific Tigers men's basketball program made three consecutive appearances in the NCAA Tournament (2004, 2005, 2006). Head coach Bob Thomason became the winningest head coach in Big West Conference men's basketball history when he collected his 206th career league victory on Feb. 14, 2009, surpassing the conference win total of former LBSU and UNLV head coach Jerry Tarkanian. Pacific has also achieved a 16-game winning streak three times under Thomason.
At the end of the 1995 season, Pacific ended its football program after 77 years of competition.
On November 12, 2012, it was announced that Pacific would add three new sports teams to its roster - a men's soccer team, a women's track and field team and a women's beach volleyball team. The two women's sports began play in 2013, and the men's soccer team began play in 2014. The most recent change in sports sponsorship was the dropping of men's volleyball at the end of the 2014 season (2013–14 school year).