Lowe moved to McLaren in 1993, when he was employed as Head of Research and Development, a department subsequently renamed Vehicle Technology. He was head of the department for eight years until, in 2001, when he was appointed Chief Engineer Systems Development, a role focusing on the race programme for the McLaren MP4-20. In May 2005 he assumed the role of Engineering Director, which gave him responsibility for all the engineering departments. In January 2011 Lowe became the team's Technical Director. Lowe moved to Mercedes F1 team as Executive Director on 3 June 2013.