Pain wind-up

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Pain wind-up is the perceived increase in pain intensity over time when a given non painful stimulus is delivered repeatedly above a critical rate. It is caused by repeated stimulation of group C peripheral nerve fibers, leading to progressively increasing electrical response in the corresponding spinal cord (posterior horn) neurons.[1] [2]

References[edit]

  1. ^ Feng Xu; Tianjian Lu (29 May 2011). Introduction to Skin Biothermomechanics and Thermal Pain. Springer. p. 347. ISBN 978-3-642-13201-8. Retrieved 25 April 2012. 
  2. ^ Pitcher and Henry. (2000), Eur. J. Neurosci., 12 :2006-2020