Pallidotomy is a neurosurgical procedure whereby a tiny electrical probe is placed in the globus pallidus (one of the basal ganglia of the brain), which is then heated to 80 degrees Celsius for 60 seconds, to destroy a small area of brain cells.
Pallidotomy is an alternative to deep brain stimulation for the treatment of the involuntary movements known as dyskinesias which can become a problem in people with Parkinson's disease after long-term treatment with levodopa — a condition known as levodopa-induced dyskinesia. It is also sometimes used in alternative to deep brain stimulation to treat difficult cases of essential tremor.
Stereotactic pallidotomy was pioneered by Dr. Hirotaro Narabayashi.
- Oertel, W.H.; Berardelli, A.; Bloem, B.R.; Bonuccelli, U.; Burn, D.; Deuschl, G.; et al (2011). "Ch. 15: Late (complicated) Parkinson's disease". In Gilhus, Nils Erik; Barnes, Michael R.; Brainin, Michael. European Handbook of Neurological Management I (2nd ed.). Blackwell. pp. 240–1. ISBN 978-1-405-18533-2. Retrieved 31 October 2012.
- Hooper, AK; Okun, MS; Foote, KD; Fernandez, HH; Jacobson, C; Zeilman, P; Romrell, J; Rodriguez, RL (2008). "Clinical cases where lesion therapy was chosen over deep brain stimulation". Stereotactic and functional neurosurgery 86 (3): 147–52. doi:10.1159/000120426. PMID 18334856.