In 2002 Reed was the first woman to become the overall winner of the Badwater Ultramarathon. She subsequently repeated as overall winner of the race in 2003. In 2002, her win also set the women's course record.
In 2003, she set the women's record for the USATF 24-hour track run, which she still holds.
In 2005, she completed a 300-mile run without sleep. She completed the run in slightly less than eighty hours.