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For detailed information about the active ingredient in Panadol, see Paracetamol, also known as acetaminophen
Panadol 500 mg tablets
Panadol Rapid 500 mg caplets

Panadol is one of GlaxoSmithKline's trade names for paracetamol (INN) (/ˌpærəˈstəmɒl/ or /ˌpærəˈsɛtəmɒl/) or acetaminophen (USAN) Listeni/əˌstəˈmɪnəfɨn/, which is an analgesic (pain reliever) and antipyretic (fever reducer). According to GlaxoSmithKline, Panadol is marketed in 85 countries,[1] including Australia,[2] Belgium,[3] Brazil,[3] Bulgaria,[3] Chile,[3] Finland,[3] France,[3] Greece,[3] Hong Kong,[3] Indonesia,[3] Ireland,[3] Italy,[3] Korea,[3] Netherlands,[3] New Zealand,[4] Nigeria,[5] the Philippines,[3] Peru,[1] Pakistan, the Kingdom of Saudi Arabia, South Africa,[3] Sri Lanka, Switzerland,[3] Taiwan,[3] Thailand, Trinidad and Tobago, [3] the United Kingdom, Malta, and Uruguay.[3]


In 1955, Panadol was introduced to hospitals in the United Kingdom.[6] It was first marketed by Phillips, Scott & Turner, which was acquired by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. It was advertised as being "gentle on the stomach", since other analgesic agents at the time contained aspirin, a known stomach irritant. Panadol was originally available only by prescription in the UK, but is now available over the counter. In 1983, Sterling introduced Panadol to the United States market.[7] In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994.[8] It has been called "one of the most-frequently counterfeited medicines in the world."[9]

Other brand names[edit]

Other GlaxoSmithKline brand names of paracetamol include Panodil (marketed in Denmark, Norway, and Sweden), Calpol (marketed in India, Ireland, Israel, Japan, Puerto Rico, South Africa, Thailand and the United Kingdom) and Crocin (the most popular paracetamol brand in India).[3][10][11]

Other formulations and packaging[edit]

Panadol is sold in different formulations and packaging with different names, including:

  1. Panadol
  2. Panadol Extra
  3. Panadol Rapid
  4. Panadol Night
  5. Panadol Extra Strength (sold in Latin America-based countries)
  6. Panadol Multi-Symptom (sold in Latin America-based countries)
  7. Panadol Osteo
  8. Panadol Extend Tablets
  9. Panadol with Optizorb (sold in the Philippines)
  10. Panadol Rapid Handipak (sold in Australia)
  11. Panadol Cold and Catarrh (sold in Nigeria)[12]
  12. Panadol Cold and Flu (sold in Greece, United Kingdom and some parts of Latin America)
  13. Panadol Fever and Congestion (sold in Ireland)
  14. Panadol ActiFast (sold in Malaysia)[13]
  15. Panadol with Optizorb[1]

Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol. Studies have reached conflicting conclusions regarding the clinical significance of this incremental pain relief.[14][15]

Panadol Osteo and Panadol Extend Tablets are modified-release formulations of paracetamol.[16] Panadol Osteo is marketed in Australia and New Zealand; its immediate to sustained release ratio is 33% to 66%.[17]

Panadol Rapid Handipak is Panadol Rapid packaged in a slim container of ten 500 mg caplets, designed to appeal to Australian women who are 20 to 35 years of age.[18][19]

Panadol Cold and Catarrh contains three active ingredients: paracetamol, phenylephrine hydrochloride as a nasal decongestant, and chlorpheniramine maleate to prevent certain allergies.[12]

Panadol Cold and Flu and Panadol Fever and Congestion both combine paracetamol with phenylephrine hydrochloride as a nasal decongestant.[4][20]


  1. ^ a b c Crisostomo, Sheila (30 January 2014). "GSK launches paracetamol brand in Phl". The Philippine Star. 
  2. ^ Agence France-Presse (26 February 2014). "Pain reliever acetaminophen linked to ADHD". (News Limited). 
  3. ^ a b c d e f g h i j k l m n o p q r s t Weiner, Carl P.; Buhimschi, Catalin (2009). Drugs for Pregnant and Lactating Women. Elsevier Health Sciences. p. 37. ISBN 1-4377-2136-2. 
  4. ^ a b Mathewson, Nicole (20 March 2014). "Flu remedies pose dosage risk". The Press (Fairfax Media Digital). Retrieved 25 March 2014. 
  5. ^ Akpotaire, Ufuoma (22 September 2013). "A peek into sex passing-off cases in Nigeria". NLIPW Trademark Law 1 (12) (Nigerian Law Intellectual Property Watch). Retrieved 25 March 2014. 
  6. ^ GlaxoSmithKline | Panadol 50 Years
  7. ^ Hollie, Pamela G. (14 March 1983). "Sterling to Try Again with a Nonaspirin Drug". New York Times. Retrieved 20 May 2015. 
  8. ^ SEC Info| Eastman Kodak Co | 8-K | For 6/30/94
  9. ^ "Simple counterfeit drugs test developed". UPI. 26 August 2012. Retrieved 20 May 2015. 
  10. ^ "Merger of painkiller manufacturers to be scrutinised" (Press release). Konkurrensverket, Swedish Competition Authority. 18 February 2009. Retrieved 25 March 2014. 
  11. ^ Paliwal, Ankur (8 December 2011). "Govt prescribes placebos for drug price control, charge activists". Business Standard. 
  12. ^ a b Okonta, Chuks Udo; Agboola, Toba (25 December 2008). "GlaxoSmithKline unveils Panadol Cold & Catarrh". The Nation. 
  13. ^ "Panadol ActiFast". 
  14. ^ Derry, Christopher J; Derry, Sheena; Moore, R Andrew (11 December 2014). "Caffeine as an analgesic adjuvant for acute pain in adults". Cochrane database of systematic reviews. doi:10.1002/14651858.CD009281.pub3. PMID 25502052. 
  15. ^ "Paracetamol with caffeine (Panadol Extra) available over the counter from pharmacies". NPS Radar. National Prescribing Service. Retrieved 10 August 2012. 
  16. ^ Graudins, A.; Chiew, A.; Chan, B. (2010). "Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol" (PDF). Internal Medicine Journal 40 (1): 72–76. doi:10.1111/j.1445-5994.2009.02096.x. ISSN 1444-0903. PMID 20561368. 
  17. ^ Graudins, Andis; Pham, Hanh Ngoc; Salonikas, Chris; Naidoo, Daya; Chan, Betty (2009). "Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption". New Zealand Medical Journal 122 (1300): 64–71. ISSN 1175-8716. 
  18. ^ Vaczek, David (9 December 2007). "GSK's Handipak for Panadol Offers Discreet Portability". Pharmaceutical & Medical Packaging News. Retrieved 25 March 2014. 
  19. ^ "PR positions Panadol Rapid Handipak as the must have accessory for every girl's handbag!". Golden Target Awards. UTS Library, University of Technology, Sydney. Retrieved 25 March 2014. 
  20. ^ "Package leaflet: information for the user – Panadol Cold and Flu 500 mg / 30 mg Film Coated Tablets" (PDF). GlaxoSmithKline. Retrieved 25 March 2014. 

External links[edit]