Panadol is one of GlaxoSmithKline's trade names for paracetamol (INN) (// or //) or acetaminophen (USAN) i//, which is an analgesic (pain reliever) and antipyretic (fever reducer). According to GlaxoSmithKline, Panadol is marketed in 85 countries, including Australia, Belgium, Brazil, Bulgaria, Chile, England, Finland, France, Greece, Hong Kong, Indonesia, Ireland, Italy, Korea, Netherlands, New Zealand, Nigeria, the Philippines, Poland, the Kingdom of Saudi Arabia, South Africa, Switzerland, Taiwan, Thailand, the United Kingdom, and Uruguay. It is sold in the U.S.A. and Canada under the trade name of Tylenol
In 1955, Panadol was introduced to hospitals in the United Kingdom. It was first marketed by Phillips, Scott & Turner, which was acquired by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. It was advertised as being "gentle on the stomach", since other analgesic agents at the time contained aspirin, a known stomach irritant. Panadol was originally available only by prescription in the UK, but is now available over the counter. In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994.
Other GlaxoSmithKline brand names of paracetamol include Panodil (marketed in Denmark, Norway, and Sweden), Calpol (marketed in India, Ireland, Israel, Japan, Puerto Rico, South Africa, and Thailand) and Crocin (the most popular paracetamol brand in India). Panodil was cited in a medication error due to the similarity of the name to the drug Plendil.
GlaxoSmithKline was found to have infringed on the trademark of Sterling Products, a competitor in Nigeria, replacing the competing product's name with the word Panadol on a nearly identical graphical design, in a nearly identical font style and size. The 2011 ruling came 16 years after the lawsuit was initially filed by Sterling Products.
Panadol is sold in different formulations and packaging with different names, including:
- Panadol Extra
- Panadol Rapid
- Panadol Night
- Panadol Extra Strength (sold in Latin America-based countries)
- Panadol Multi-Symptom (sold in Latin America-based countries)
- Panadol Osteo
- Panadol Extend Tablets
- Panadol with Optizorb (sold in the Philippines)
- Panadol Rapid Handipak (sold in Australia)
- Panadol Cold and Catarrh (sold in Nigeria)
- Panadol Cold and Flu (sold in Greece and the United Kingdom)
- Panadol Fever and Congestion (sold in Ireland)
- Panadol ActiFast (sold in Malaysia)
Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine (65 mg) with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol, though the extent of this effect “is uncertain and may not be clinically meaningful”, according to one review.
Panadol Osteo and Panadol Extend Tablets are modified-release formulations of paracetamol. Panadol Osteo is marketed in Australia and New Zealand; its immediate to sustained release ratio is 33% to 66%.
Panadol with Optizorb reduces the time for pain-relieving levels of paracetamol to reach the blood stream to five minutes, according to GlaxoSmithKline.
Use for Lower Back Pain
The July 23, 2014 online issue of the prestigious British medical journal, The Lancet, reported that, in spite of its common use to manage lower back pain, a recent study of 1,600 patients found that acetaminophen (also known as paracetemol, with the common trade names of Tylenol and Panadol) had no effect beyond that of placebos controlling lower back pain. "Acetaminophen also did not improve patients' level of disability, sleep quality or quality of life." Experts warn that the results of one study may not be enough to change present prescribing patterns, but it should be emphasized that the recommended maximum daily dose is 4,000 milligrams (mg.).
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