Panadol is one of GlaxoSmithKline's trade names for paracetamol (INN) (// or //) or acetaminophen (USAN) i//, which is an analgesic (pain reliever) and antipyretic (fever reducer). According to GlaxoSmithKline, Panadol is marketed in 85 countries, including Australia, Belgium, Brazil, Bulgaria, Chile, England, Finland, France, Greece, Hong Kong, Indonesia, Ireland, Italy, Korea, Netherlands, New Zealand, Nigeria, the Philippines, Peru, Pakistan, the Kingdom of Saudi Arabia, South Africa, Sri Lanka, Switzerland, Taiwan, Thailand, Trinidad and Tobago,  the United Kingdom, Malta, and Uruguay.
In 1955, Panadol was introduced to hospitals in the United Kingdom. It was first marketed by Phillips, Scott & Turner, which was acquired by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. It was advertised as being "gentle on the stomach", since other analgesic agents at the time contained aspirin, a known stomach irritant. Panadol was originally available only by prescription in the UK, but is now available over the counter. In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994.
Other GlaxoSmithKline brand names of paracetamol include Panodil (marketed in Denmark, Norway, and Sweden), Calpol (marketed in India, Ireland, Israel, Japan, Puerto Rico, South Africa, and Thailand) and Crocin (the most popular paracetamol brand in India).
Panadol is sold in different formulations and packaging with different names, including:
- Panadol Extra
- Panadol Rapid
- Panadol Night
- Panadol Extra Strength (sold in Latin America-based countries)
- Panadol Multi-Symptom (sold in Latin America-based countries)
- Panadol Osteo
- Panadol Extend Tablets
- Panadol with Optizorb (sold in the Philippines)
- Panadol Rapid Handipak (sold in Australia)
- Panadol Cold and Catarrh (sold in Nigeria)
- Panadol Cold and Flu (sold in Greece, United Kingdom and some parts of Latin America)
- Panadol Fever and Congestion (sold in Ireland)
- Panadol ActiFast (sold in Malaysia)
Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine (65 mg) with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol. Studies have reached conflicting conclusions regarding the clinical significance of this incremental pain relief.
Panadol Osteo and Panadol Extend Tablets are modified-release formulations of paracetamol. Panadol Osteo is marketed in Australia and New Zealand; its immediate to sustained release ratio is 33% to 66%.
Panadol with Optizorb reduces the time for pain-relieving levels of paracetamol to reach the blood stream to five minutes, according to GlaxoSmithKline.
The active ingredient in Panadol, paracetamol, has been compared to non-steroidal anti-inflammatory drugs (NSAIDS) for the treatment of minor pain syndromes including post-surgical pain, migraine pain, and arthritis pain.
The American College of Rheumatology recommends paracetamol as one of several treatment options for patients with arthritis pain of the hip, hand, or knee that is refractory to non-pharmacological interventions such as exercise and weight loss.
A joint statement of the German, Austrian, and Swiss headache societies and the German Society of Neurology recommends the use of paracetamol in combination with caffeine as one of several first line therapies for treatment of tension or migraine headache. In the treatment of acute migraine, it is superior to placebo, with 39% of people experiencing pain relief at 1 hour compared to 20% in the control group.
Based on a systematic review, paracetamol is recommended by the American College of Physicians and the American Pain Society as a first line treatment for low back pain. However a systematic review published by other authors concluded that evidence for its efficacy is lacking.
The combination of paracetamol with caffeine is superior to paracetamol alone for the treatment of common pain conditions including dental pain, postpartum pain, and headache.
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- Panadol Australia Website
- Panadol | Consumer Healthcare | Manufacturers Website
- Panadol GlaxoSmithKline Web site