Panadol

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For detailed information about the active ingredient in Panadol, see Paracetamol, also known as acetaminophen
Panadol 500 mg tablets
Panadol Rapid 500 mg caplets

Panadol is one of GlaxoSmithKline's trade names for paracetamol (INN) (/ˌpærəˈstəmɒl/ or /ˌpærəˈsɛtəmɒl/) or acetaminophen (USAN) Listeni/əˌstəˈmɪnəfɨn/, which is an analgesic (pain reliever) and antipyretic (fever reducer). According to GlaxoSmithKline, Panadol is marketed in 85 countries,[1] including Australia,[2] Belgium,[3] Brazil,[3] Bulgaria,[3] Chile,[3] England,[3] Finland,[3] France,[3] Greece,[3] Hong Kong,[3] Indonesia,[3] Ireland,[3] Italy,[3] Korea,[3] Netherlands,[3] New Zealand,[4] Nigeria,[5] the Philippines,[3] Poland,[1] the Kingdom of Saudi Arabia, South Africa,[3] Switzerland,[3] Taiwan,[3] Thailand,[3] the United Kingdom, and Uruguay.[3] It is sold in the U.S.A. and Canada under the trade name of Tylenol

In 1955, Panadol was introduced to hospitals in the United Kingdom.[6] It was first marketed by Phillips, Scott & Turner, which was acquired by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. It was advertised as being "gentle on the stomach", since other analgesic agents at the time contained aspirin, a known stomach irritant. Panadol was originally available only by prescription in the UK, but is now available over the counter. In 1988 Sterling Winthrop was acquired by Eastman Kodak which sold the over the counter drug rights to SmithKline Beecham in 1994.[7]

Other GlaxoSmithKline brand names of paracetamol include Panodil (marketed in Denmark, Norway, and Sweden), Calpol (marketed in India, Ireland, Israel, Japan, Puerto Rico, South Africa, and Thailand) and Crocin (the most popular paracetamol brand in India).[3][8][9] Panodil was cited in a medication error due to the similarity of the name to the drug Plendil.[10]

GlaxoSmithKline was found to have infringed on the trademark of Sterling Products, a competitor in Nigeria, replacing the competing product's name with the word Panadol on a nearly identical graphical design, in a nearly identical font style and size.[5] The 2011 ruling came 16 years after the lawsuit was initially filed by Sterling Products.[5]

Panadol is sold in different formulations and packaging with different names, including:

  1. Panadol
  2. Panadol Extra
  3. Panadol Rapid
  4. Panadol Night
  5. Panadol Extra Strength (sold in Latin America-based countries)
  6. Panadol Multi-Symptom (sold in Latin America-based countries)
  7. Panadol Osteo
  8. Panadol Extend Tablets
  9. Panadol with Optizorb (sold in the Philippines)
  10. Panadol Rapid Handipak (sold in Australia)
  11. Panadol Cold and Catarrh (sold in Nigeria)[11]
  12. Panadol Cold and Flu (sold in Greece and the United Kingdom)
  13. Panadol Fever and Congestion (sold in Ireland)
  14. Panadol ActiFast (sold in Malaysia)[12]

Panadol Extra, an S2 pharmacy-only medicine in Australia, combines 65 mg of caffeine (65 mg) with 500 mg of paracetamol per tablet. Caffeine may improve the analgesic effect of paracetamol, though the extent of this effect “is uncertain and may not be clinically meaningful”, according to one review.[13]

Panadol Osteo and Panadol Extend Tablets are modified-release formulations of paracetamol.[14] Panadol Osteo is marketed in Australia and New Zealand; its immediate to sustained release ratio is 33% to 66%.[15]

Panadol with Optizorb reduces the time for pain-relieving levels of paracetamol to reach the blood stream to five minutes, according to GlaxoSmithKline.[1]

Panadol Rapid Handipak is Panadol Rapid packaged in a slim, stylish, plastic container of ten 500 mg caplets, designed to appeal to Australian women who are 20–35 years of age.[16][17]

Panadol Cold and Catarrh contains three active ingredients: paracetamol, phenylephrine hydrochloride as a nasal decongestant, and chlorpheniramine maleate to prevent certain allergies.[11]

Panadol Cold and Flu and Panadol Fever and Congestion both combine paracetamol with phenylephrine hydrochloride as a nasal decongestant.[4][18]

Use for Lower Back Pain[edit]

The July 23, 2014 online issue of the prestigious British medical journal, The Lancet, reported that, in spite of its common use to manage lower back pain, a recent study of 1,600 patients found that acetaminophen (also known as paracetemol, with the common trade names of Tylenol and Panadol) had no effect beyond that of placebos controlling lower back pain. "Acetaminophen also did not improve patients' level of disability, sleep quality or quality of life." Experts warn that the results of one study may not be enough to change present prescribing patterns, but it should be emphasized that the recommended maximum daily dose is 4,000 milligrams (mg.).[19][20]

See also[edit]

Vitamin C

References[edit]

  1. ^ a b c Crisostomo, Sheila (30 January 2014). "GSK launches paracetamol brand in Phl". The Philippine Star. 
  2. ^ Agence France-Presse (26 February 2014). "Pain reliever acetaminophen linked to ADHD". News.com.au (News Limited). 
  3. ^ a b c d e f g h i j k l m n o p q r s t u Weiner, Carl P.; Buhimschi, Catalin (2009). Drugs for Pregnant and Lactating Women. Elsevier Health Sciences. p. 37. ISBN 1-4377-2136-2. 
  4. ^ a b Mathewson, Nicole (20 March 2014). "Flu remedies pose dosage risk". The Press (Fairfax Media Digital). Retrieved 25 March 2014. 
  5. ^ a b c Akpotaire, Ufuoma (22 September 2013). "A peek into sex passing-off cases in Nigeria". NLIPW Trademark Law 1 (12) (Nigerian Law Intellectual Property Watch). Retrieved 25 March 2014. 
  6. ^ GlaxoSmithKline | Panadol 50 Years
  7. ^ SEC Info| Eastman Kodak Co | 8-K | For 6/30/94
  8. ^ "Merger of painkiller manufacturers to be scrutinised" (Press release). Konkurrensverket, Swedish Competition Authority. 18 February 2009. Retrieved 25 March 2014. 
  9. ^ Paliwal, Ankur (8 December 2011). "Govt prescribes placebos for drug price control, charge activists". Business Standard. 
  10. ^ Criscuolo, Domenico (March 2014). "Tackling Medication Errors – an EMA Workshop". IFAPP WORLD (IFAPP). Retrieved 25 March 2014. 
  11. ^ a b Okonta, Chuks Udo; Agboola, Toba (25 December 2008). "GlaxoSmithKline unveils Panadol Cold & Catarrh". The Nation. 
  12. ^ "Panadol ActiFast". 
  13. ^ "Paracetamol with caffeine (Panadol Extra) available over the counter from pharmacies". NPS Radar. National Prescribing Service. Retrieved 10 August 2012. 
  14. ^ Graudins, A.; Chiew, A.; Chan, B. (2010). "Overdose with modified-release paracetamol results in delayed and prolonged absorption of paracetamol" (PDF). Internal Medicine Journal 40 (1): 72–76. doi:10.1111/j.1445-5994.2009.02096.x. ISSN 1444-0903. 
  15. ^ Graudins, Andis; Pham, Hanh Ngoc; Salonikas, Chris; Chan, Daya (2009). "Early presentation following overdose of modified-release paracetamol (Panadol Osteo) with biphasic and prolonged paracetamol absorption". New Zealand Medical Journal 122 (1300): 64–71. ISSN 1175-8716. 
  16. ^ Vaczek, David (9 December 2007). "GSK's Handipak for Panadol Offers Discreet Portability". Pharmaceutical & Medical Packaging News. Retrieved 25 March 2014. 
  17. ^ "PR positions Panadol Rapid Handipak as the must have accessory for every girl's handbag!". Golden Target Awards. UTS Library, University of Technology, Sydney. Retrieved 25 March 2014. 
  18. ^ Package leaflet: information for the user – Panadol Cold and Flu 500 mg / 30 mg Film Coated Tablets (PDF). GlaxoSmithKline. Retrieved 25 March 2014. 
  19. ^ "Acetaminophen May Not Help Against Back Pain, Study Contends" Web MD [1]
  20. ^ "Acetaminophen may do little for acute back pain." Harvard Health blog. [2]

External links[edit]