Panos G. Georgopoulos

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Panos G. Georgopoulos, Ph.D. is a scientist working in the field of Environmental Health and specializing in Mathematical Modeling of Environmental and Biological Systems. He is the architect or the MOdeling ENvironment for Total Risk studies (MENTOR) [1] [2] [3] [4] [5] and the DOse Response Information and Analysis system (DORIAN),[3][6] both under continuing development at the Computational Chemodynamics Laboratory of the Environmental and Occupational Health Sciences Institute (EOHSI). Funding for his work has been provided by the United States Environmental Protection Agency, United States Department of Energy, National Institutes of Health, Centers for Disease Control, New Jersey Department of Environmental Protection, New Jersey Department of Health and Senior Services, American Chemistry Council, and other public and private agencies.

Biography[edit]

Georgopoulos is Professor of Environmental and Occupational Medicine at the University of Medicine and Dentistry of New Jersey - Robert Wood Johnson Medical School. He is also a member of the Graduate Faculties of Chemical and Biochemical Engineering, Biomedical Engineering, and of Environmental Sciences at Rutgers University, and a member of the Environmental and Occupational Health Sciences Institute (EOHSI), which is a joint institute of UMDNJ-RWJMS and Rutgers. Georgopoulos received his M.S. and Ph.D. Degrees in Chemical Engineering from the California Institute of Technology (Caltech) and his Dipl. Ing. Degree from the National Technical University of Athens. At EOHSI he established and directs the Computational Chemodynamics Laboratory (CCL), a state-of-the-art facility for informatics and modeling of complex environmental and biological systems. Furthermore, he directs the State-funded Ozone Research Center and co-directs the Center for Exposure and Risk Modeling (CERM) at EOHSI. He is Co-Director of the Environmental Bioinformatics and Computational Toxicology Center (ebCTC), a research consortium of University of Medicine and Dentistry of New Jersey, Princeton University, Rutgers University and the U.S. Food and Drug Administration's Center for Toxicoinformatics. He is also Co-Director of the Bioinformatics, Biostatistics and Computational Toxicology Core for the NIEHS Center for Environmental Exposures and Disease (CEED) at EOHSI. He served as Director of the USDOE-funded Center of Expertise in Exposure Assessment of the Consortium for Risk Evaluation with Stakeholder Participation (CRESP).

Georgopoulos has participated in both research and teaching in the graduate programs of Rutgers and UMDNJ-RWJMS and has developed innovative course materials in modeling and informatics related to environmental health applications. He has been the primary doctoral thesis advisor to 18 students, with 11 Ph.D. degrees awarded since 1997, and has been mentor to 24 post-doctoral fellows. His research interests involve the development and application of novel mathematical and computational methods for diagnostic and mechanistic studies of multipathway physicochemical processes taking place in interacting environmental and biological systems. The aim of this research is to improve the understanding and quantification of human exposure and biological mechanism-based dosimetry and risk for environmental toxics; this is being accomplished through the ongoing development of a consistent mechanistic multiscale modular computational framework for source-to-dose-to-effect modeling of toxicant dynamics. Outcomes of this research include integrative computational models of toxicokinetic and toxicodynamic processes at the cellular, tissue and whole body levels.

Georgopoulos has lectured as an invited speaker at universities, including the Harvard School of Public Health, Johns Hopkins University, Stanford University, Illinois Institute of Technology, University of Minnesota, and others. He has published more than 125 peer-reviewed articles and chapters in scientific journals, books and proceedings, and has authored or co-authored several State and Federal Government Documents and numerous technical reports. He has received awards and honors, including the DuPont Education and Research Award, for his work on environmental pollution and health. He served on editorial boards of scientific journals and currently serves as member of various national and international scientific and technical committees on environmental issues.

Georgopoulos works in close association with Paul J. Lioy, Director of the Exposure Science Division of EOHSI.

Education[edit]

  • 1986 - Ph.D., Chemical Engineering, California Institute of Technology, Pasadena, California, U.S.A.
  • 1982 - M.S., Chemical Engineering, California Institute of Technology, Pasadena, California, U.S.A.
  • 1980 - Dipl. Ing., Chemical Engineering, National Technical University, Athens, Greece

Research interests[edit]

Mathematical modeling of environmental and biological systems and their interactions - computational chemodynamics and toxicodynamics[edit]

  • Multimedia transport, fate and uptake of environmental pollutants; photochemical smog; air toxics; persistent organics; heavy metals
  • Physiologically-based toxicokinetics and pharmacokinetics; inhalation, ingestion and dermal absorption dosimetry
  • Mechanistic toxicodynamics and pharmacodynamics
  • Computational systems toxicology and toxicogenomics
  • Multiscale biological modeling (from molecule to cell to tissue to organism to population) for toxicity and environmental health assessment

Environmental and human exposure information systems methods[edit]

  • Multidimensional/spatiotemporal data mining and diagnostic analysis via Geographic Information and Database Management Systems
  • Multiroute/multipathway modeling of human exposure to toxics
  • Enviroinformatics, cheminformatics, and bioinformatics

Risk and uncertainty analysis methods[edit]

  • Uncertainty characterization, analysis and reduction methods for environmental and occupational health risk assessment

Professional career[edit]

Current academic appointments[edit]

  • 2010–present: Co-Director, Environmental Bioinformatics and Computational Toxicology Center – a UMDNJ-RWJMS - Rutgers - Princeton - USFDA Research Consortium
  • 2009–present: Associate Member, Cancer Institute of New Jersey, UMDNJ - Robert Wood Johnson Medical School
  • 2007–present: Co-Director, Bioinformatics, Biostatistics and Computational Toxicology Core, NIEHS Center for Environmental Exposures and Disease at EOHSI
  • 2004–present: Professor, Department of Environmental and Occupational Medicine, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ
  • 2002–present: Member, Graduate Faculty, Department of Biomedical Engineering, Rutgers University
  • 2000–present: Co-Director, Center for Exposure and Risk Modeling (CERM), Environmental and Occupational Health Sciences Institute, Piscataway, NJ
  • 1994–present: Director, Ozone Research Center, Environmental and Occupational Health Sciences Institute, Piscataway, NJ
  • 1992–present: Director, Computational Chemodynamics Laboratory, Environmental and Occupational Health Sciences Institute, Piscataway, NJ
  • 1991–present: Member, Graduate Faculty, Department of Environmental Sciences, Rutgers University
  • 1990–present: Member, Graduate Faculty, Department of Chemical and Biochemical Engineering, Rutgers University
  • 1989–present: Member, Environmental and Occupational Health Sciences Institute, Piscataway, NJ

Selected honors and awards[edit]

  • International Society for Environmental Epidemiology (ISEE) Citation of Appreciation (1999) for Leadership, Organization, and Exceptional Effort as Co-Chair of the Organizing Committee for the 1999 Conference
  • International Society of Exposure Analysis (ISEA) Certificate in Appreciation of Service (1999) as Technical Program Chair of the 1999 Annual Conference
  • U.S. EPA Certificate of Appreciation (1999) (for Contributions to the Development of Models-3)
  • The DuPont Educational Award (1996)
  • The PSE&G Educational Grant (1996)
  • The DuPont Educational Award (1995)
  • Society of Toxicology, Best Presentation in Risk Assessment Award (1994)
  • The Dodecanesian Service Award (1992)

Editorial positions[edit]

  • 2001-2004: Member of Editorial Board, Stochastic Environmental Research and Risk Assessment
  • 1999: Guest Co-Editor, Epidemiology (Supplement) (vol. 10, July 1999)
  • 1995: Guest Co-Editor, Environmental Health Perspectives (vol. 103, March 1995, Supplement 2): Environmental Epidemiology, Health Effects of Ozone and Perinatal Exposure to Dioxins
  • 1995-2001: Associate Editor, Journal of the Air and Waste Management Association

Georgopoulos also served as a reviewer for, among others, the following journals: Atmospheric Environment; Water, Air, and Soil Pollution; Environmental Health Perspectives; Environmental Research; Environmental Science and Technology; Environmental Engineering Science; Journal of Exposure Science and Environmental Epidemiology; Journal of the Air and Waste Management Association; Journal of Computational Chemistry; Journal of Physical Chemistry; Journal of Hazardous Materials; and Science of the Total Environment.

Service on grant review panels, study sections, and committees[edit]

  • 2010-2011: Member, Virtual Physiological Human (VPH) International Expert Group
  • 2010-2011: Member, FIFRA Scientific Advisory Panel (FIFRA SAP) on scientific issues associated with Chlorpyrifos
  • 2010: Member, USEPA Grant Review Panel, Computational Toxicology: Biologically-Based Multiscale Modeling
  • 2010: Member, USEPA Exposure Factors Handbook (EFH) Peer Review Committee
  • 2010: Member, External Scientific Advisory Panel, EU TAGS Project
  • 2009: Member, USEPA Review Panel for Indoor Air Formaldehyde Modeling
  • 2009: Member, Joint USEPA-European Union Science Panel for Virtual Tissues
  • 2008: Member, USEPA Review Panel for Perchlorate Pharmacokinetics Modeling
  • 2008: Member, NIH Review Panel, Instrumentation and Systems Development
  • 2007: Member, USEPA Review Panel for Computational Toxicology STAR Grants
  • 2007: Member, USEPA Child Specific Exposure Factors Handbook (CSEFH) Peer Review Committee
  • 2006: Member, NIH Grant Review Panel: Arthritis, Connective Tissue and Skin Study Section (ACTS)
  • 2005-2006: Member of USEPA's Science Advisory Board (SAB) Regulatory Environmental Modeling (REM) Guidance Review Panel
  • 2003-2004: Reviewer, Cancer Institute of New Jersey Exploratory Research Grants
  • 2001-2002: Member, Air Quality Modeling Subcommittee (AQMS) of the Advisory Council on Clean Air Compliance Analysis (for USEPA's Study of the Costs and Benefits of the Clean Air Act, 2000–2020)
  • 2001-2002: Member, Environmental Modeling Subcommittee, National Air Toxics Assessment (NATA) Panel of EPA’s Scientific Advisory Board
  • 2001–present: Reviewer, American Chemical Society Research Grants Program
  • 2000–present: Reviewer, National Aeronautics and Space Administration (NASA) Life Sciences Division Research Program
  • 2000-2007: Reviewer, USEPA Office of Prevention, Pesticides and Toxics Research Program
  • 1999-2001: Member, Chemical Manufacturers Association Exposure Assessment Research Program Advisory Workgroup
  • 1999–present: Reviewer, National Science Foundation Computational Mathematics (for Environmental Applications) Grant Program
  • 1998-2001: Member, US Environmental Protection Agency Attainment Demonstration Guidance Review Workgroup
  • 1994–present: Chemistry and Modeling Committee Member, North American Research Strategy for Tropospheric Ozone (NARSTO)
  • 1994-1996: Member, Coordinating Committee of the NARSTO-Northeast Project
  • 1992-1993: Working Group Member, USEPA Reassessment of Dioxin Project
  • 1991-1992: Grant Review Panel Member, US Department of Energy Atmospheric Chemistry Program
  • 1990-1994: National Modeling Committee Member, Regional Oxidant Modeling for Northeast Transport (ROMNET) Project

Service on graduate school committees[edit]

  • 2001–present: Member, Steering Committee, Informatics Institute of UMDNJ
  • 2001–present: Member, EOHSI Center for International Health Committee
  • 2000-2002: Member, EOHSI Subcommittee on Future Research Directions
  • 2000-2002: Member, EOHSI Membership Renewal and Criteria Committee
  • 1995-1997: Member, Committee for the Development of a Graduate Program in Environmental Engineering at Rutgers University
  • 1994-1995: Member, Interdisciplinary Campus-wide Environmental Science and Engineering Curriculum Assessment Committee
  • 1993-1994: Member, Cook College (Rutgers University) Environmental Vision Planning Committee
  • 1991-1993: Member, College of Engineering (Rutgers University) Graduate Recruitment Committee

Service to the community[edit]

  • 2010–present: Member, Executive Committee, Modern Greek Studies Program, Rutgers University
  • 2010–present: President, Agios Gerasimos Cephalonian Association of NJ
  • 2004-2007: Member, Board of Trustees, St George Greek Orthodox Church of Piscataway, New Jersey
  • 2003–present: Director, St George Greek School, Piscataway, NJ
  • 2003–present: Member, Central New Jersey AHEPA Educational Awards Committee
  • 1997–present: Technical Advisory Board Member, EnviroComp Institute (www.envirocomp.org)
  • 1993–present: Chairman of the Board of Trustees, Elytis Chair Fund at Rutgers University
  • 1986–present: Technical/Scientific Advisor or Consultant: California Air Resources Board, U.S. Environmental Protection Agency, American Petroleum Institute, American Chemistry Council, New York City Law Department, Veterans Health Administration, etc.
  • 1990-1999: Modeling Committee Member, Northeast States for Coordinated Air Use and Management (NESCAUM)
  • 1997-1998: Faculty Advisor, Hellenic Premedical Association at Rutgers University
  • 1993-1997: Faculty Advisor, Hellenic Cultural Association at Rutgers University
  • 1990-1997: Modeling Coordinator (Chair), Philadelphia Consolidated Metropolitan Statistical Area Ozone Attainment State Implementation Plan Preparation
  • 1990-1997: Modeling Committee Member, New York Metropolitan Statistical Area Ozone Attainment State Implementation Plan Preparation
  • 1992-1996: Substitute Member, Clean Air Council of New Jersey
  • 1991-1993: Technical Advisory Committee Member, Greenpoint/Williamsburg Environmental Benefits Program
  • 1989-1991: Technical Committee Member, Project: Clean Air (for the State of New Jersey and the Delaware Valley Area)

Publications[edit]

Peer-reviewed journal articles[edit]

Selected from the past 10 years:

  1. Isukapalli S., Roy A. and Georgopoulos P.G. (2000). Efficient sensitivity/uncertainty analysis using the combined Stochastic Response Surface Method (SRSM) and Automatic Differentiation for FORTRAN code (ADIFOR): Application to environmental and biological systems. Risk Analysis 20: 591-602. doi:10.1111/0272-4332.205054
  2. Broday D. and Georgopoulos P.G. (2001). Growth and deposition of hygroscopic particulate matter in the human lungs. Aerosol Science and Technology 34: 144-159. doi:10.1080/02786820118725
  3. Drossinos Y., Kevrekedis P.G. and Georgopoulos P.G. (2001). Translational invariance in nucleation theories: Theoretical formulation. Physical Review E 63: 036123.1-036123.13. doi:10.1103/PhysRevE.63.036123
  4. Georgopoulos P.G., Roy A., Yonone-Lioy M.J., Opiekun R.E. and Lioy P.J. (2001). Environmental copper: Its dynamics and human exposure issues. Journal of Toxicology and Environmental Health-Part B-Critical Reviews 4 (4): 341-394. doi:10.1080/109374001753146207
  5. Balakrishnan S., Banerjee I., Georgopoulos P.G. and Ierapetritou M. (2002). Uncertainty considerations for describing complex reaction systems. AIChE Journal 48 (12): 2875-2889. doi:10.1002/aic.690481215
  6. Weisel C., Cody R., Georgopoulos P., Purushothaman V., Weiss S., Bielory L., Gregory P. and Stern A. (2002). Concepts in developing health-based indicators for ozone. International Archives of Occupational and Environmental Health 75 (6): 415-422. doi:10.1007/s00420-002-0318-4
  7. Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2003). Uncertainty reduction and characterization for complex environmental fate and transport models: An empirical Bayesian framework incorporating the stochastic response surface method. Water Resources Research 39 (12): 1350. doi:10.1029/2002WR001810
  8. Foley G., Georgopoulos P.G. and Lioy P.J. (2003). Examining Accountability for Changes in Population Exposures to 8-Hour Ozone Standard With Implementation of Different Control Strategies. Environmental Science and Technology 37 (21): 302A-309A. doi:10.1021/es032605b
  9. Li G., Artamonov M., Rabitz H., Wang S.W., Georgopoulos P.G. and Demiralp M. (2003). High Dimensional Model Representations generated from low order terms – 1p-RS-HDMR. Journal of Computational Chemistry 24: 647-656. doi:10.1002/jcc.10232
  10. Li G., Rabitz H., Wang S.W. and Georgopoulos P.G. (2003). Correlation method for variance reduction of Monte Carlo integration in RS-HDMR. Journal of Computational Chemistry 24: 277-283. doi:10.1002/jcc.10172
  11. Roy A., Ouyang M., Freeman N., Georgopoulos P.G. and Lioy P.J. (2003). Environmental, dietary, demographic, and activity variables associated with biomarkers of exposure for benzene and lead. Journal of Exposure Analysis and Environmental Epidemiology 13 (6): 417-426. doi:10.1038/sj.jea.7500296
  12. Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2003). Random Sampling-High Dimensional Model Representation (RS-HDMR) with nonuniformly distributed variables: Application to an integrated multimedia/multipathway exposure and dose model for trichloroethylene. Journal of Physical Chemistry A 107 (23): 4707-4716. doi:10.1021/jp022500f
  13. Georgopoulos P.G., Fedele P., Shade P., Lioy P., Hodgson M., Longmire J., Sands M. and Brown M.A. (2004). Hospital response to chemical terrorism: Personal protective equipment, training, and operations planning. American Journal of Industrial Medicine 46: 432-445. doi:10.1002/ajim.20075
  14. Huber A., Georgopoulos P., Gilliam R., Stenchikov G., Wang S.-W., Kelly B. and Feingersh H. (2004). Modeling Air Pollution from the Collapse of the World Trade Center and Assessing the Potential Impacts on Human Exposures. Environmental Manager February 2004: 35-40.
  15. Landrigan P.J., Lioy P.J., Thurston G., Berkowitz G., Chen L.C., Chillrud S.N., Gavett S.H., Georgopoulos P.G., Geyh A.S., Levin S., Perera F., Rappaport S.M. and Small C. (2004). Health and environmental consequences of the World Trade Center disaster. Environmental Health Perspectives 112 (6): 731-739. doi:10.1289/ehp.6702
  16. Lazaridis M., Spyridaki A., Solberg S., Kallos G., Svendby T., Flatøy F., Drossinos I., Housiadas C., Smolik J., Colbeck I., Varinou M., Gofa F., Eleftheriadis K., Zdimal V. and Georgopoulos P.G. (2004). Modeling of Combined Aerosol and Photooxidant Processes in the Mediterranean Area. Water, Air, and Soil Pollution: Focus V4 (4): 3-21. doi:10.1023/B:WAFO.0000044782.25884.35
  17. Ouyang M., Welsh W.J. and Georgopoulos P. (2004). Gaussian mixture clustering and imputation of microarray data. Bioinformatics 20 (6): 917-23. doi:10.1093/bioinformatics/bth007
  18. Vette A., Gavett S., Perry S., Heist D., Huber A., Lorber M., Lioy P., Georgopoulos P., Rao S.T., Petersen W., Hicks B., Irwin J. and Foley G. (2004). Environmental Research in Response to 9/11 and Homeland Security. Environmental Manager February 2004: 14-22.
  19. Vyas V.M., Tong S.N., Uchrin C., Georgopoulos P.G. and Carter G.R. (2004). Geostatistical estimation of horizontal hydraulic conductivity for the Kirkwood-Cohansey aquifer. Journal of the American Water Resources Association 40 (1): 187-195. doi:10.1111/j.1752-1688.2004.tb01018.x
  20. Balakrishnan S., Roy A., Ierapetritou M.G., Flach G.P. and Georgopoulos P.G. (2005). A comparative assessment of efficient uncertainty analysis techniques for environmental fate and transport models: Application to the FACT model. Journal of Hydrology 307 (1-4): 204–218. doi:10.1016/j.jhydrol.2004.10.010
  21. Georgopoulos P.G., Wang S.W., Vyas V.M., Sun Q., Burke J., Vedantham R., McCurdy T. and Ozkaynak H. (2005). A source-to-dose assessment of population exposures to fine PM and ozone in Philadelphia, PA, during a summer 1999 episode. Journal of Exposure Analysis and Environmental Epidemiology 15 (5): 439−457. doi:10.1038/sj.jea.7500422
  22. Lazaridis M., Spyridaki A., Solberg S., Smolik J., Zdimal V., Eleftheriadis K., Aleksaropoulou V., Hov O. and Georgopoulos P.G. (2005). Mesoscale modeling of combined aerosol and photo-oxidant processes in the Eastern Mediterranean. Atmospheric Chemistry and Physics 5: 927-940. [1]
  23. Wang S.W., Balakrishnan S. and Georgopoulos P.G. (2005). Fast Equivalent Operational Model of Tropospheric Alkane Photochemistry. AIChE Journal 51 (4): 1297-1303. doi:10.1002/aic.10431
  24. Wang S.W., Georgopoulos P.G., Li G. and Rabitz H. (2005). Characterizing uncertainties in human exposure modeling through the Random Sampling-High Dimensional Model Representation (RS-HDMR) methodology. International Journal of Risk Assessment and Management 5: 387-406. doi:10.1504/IJRAM.2005.007179
  25. Wintermyer M., Skiadas A., Roy A., Yang Y.C., Georgopoulos P., Burger J. and Cooper K. (2005). The development of a physiologically-based pharmacokinetic model using the distribution of 2 317 8-tetrachlorodibenzo-p-dioxin in the tissues of the eastern oyster (Crassostrea virginica). Marine Environmental Research 60 (2): 133-152. doi:10.1016/j.marenvres.2004.08.004
  26. Wolff M.S., Teitelbaum S.L., Lioy P.J., Santella R.M., Wang R.Y., Jones R.L., Caldwell K.L., Sjodin A., Turner W.E., Li W., Georgopoulos P. and Berkowitz G.S. (2005). Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environmental Health Perspectives 113 (6): 739-48. doi:10.1289/ehp.7694
  27. Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose Assessment to computational model implementation: The MOdeling ENvironment for TOtal Risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9 (6): 457-483. doi:10.1080/10937400600755929
  28. Georgopoulos P.G., Wang S.W., Lioy P.J., Georgopoulos I.G. and Yononne-Lioy M.J. (2006). Assessment of human exposure to copper: A case study using the NHEXAS database. Journal of Exposure Science and Environmental Epidemiology 16: 397-409. doi:10.1038/sj.jea.7500462
  29. Hore P., Zartarian V., Xue J., Özkaynak H., Wang S.-W., Yang Y.-C., Chu P.-L., Sheldon L., Robson M., Needham L., Barr D., Freeman N., Georgopoulos P. and Lioy P.J. (2006). Children’s residential exposure to chlorpyrifos: Application of CPPAES field measurements of chlorpyrifos and TCPy within MENTOR/SHEDS pesticides model. Science of The Total Environment 366 (2-3): 525-537. doi:10.1016/j.scitotenv.2005.10.012
  30. Li G., Hu J., Wang S.W., Georgopoulos P.G., Schoendorf J. and Rabitz H. (2006). Random Sampling-High Dimensional Model Representation (RS-HDMR) and orthogonality of its different order component functions. Journal of Physical Chemistry A 110 (7): 2474-2485. doi:10.1021/jp054148m
  31. Lioy P.J. and Georgopoulos P. (2006). The anatomy of the exposures that occurred around the World Trade Center site: 9/11 and beyond. Annals of the New York Academy of Sciences 1076 (1): 54-79. doi:10.1196/annals.1371.002
  32. Stenchikov G., Lahoti N., Diner D.J., Kahn R., Lioy P.J. and Georgopoulos P.G. (2006). Multiscale plume transport from the collapse of the World Trade Center on September 11, 2001. Environmental Fluid Mechanics 6 (5): 425-450. doi:10.1007/s10652-006-9001-8
  33. Vyas V.M., Roy A., Strawderman W., Georgopoulos P.G. and Kosson D.S. (2006). Development and application of methodologies for determining background groundwater quality at the Savannah River site. Journal of the Air and Waste Management Association 56 (2): 159-168. [2]
  34. Vyas V.M., Sussman N., Gochfeld M., Georgopoulos P.G. and Lioy P.J. (2006). An evaluation of the role of risk based decision making in a former manufactured gas plant site remediation. Journal of the Air and Waste Management Association 56 (2): 225-235. [3]
  35. Lioy P.J., Vallero D., Foley G., Georgopoulos P., Heiser J., Watson T., Reynolds M., Daloia J., Tong S. and Isukapalli S. (2007). A personal exposure study employing scripted activities and paths in conjunction with atmospheric releases of perfluorocarbon tracers in Manhattan, New York. Journal of Exposure Science and Environmental Epidemiology 17 (5): 409-425. doi:10.1038/sj.jes.7500567
  36. Georgopoulos P. (2008). A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water, Air, and Soil Pollution: Focus 8 (1): 3-21. doi:10.1007/s11267-007-9137-7
  37. Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2008). Response to "µg/kg-day or µg/day: A commentary on Georgopoulos et al., JESEE 2008". J Expos Sci Environ Epidemiol 18 (6): 536-537. doi:10.1038/jes.2008.54
  38. Georgopoulos P.G., Wang S.-W., Yang Y.-C., Xue J., Zartarian V.G., McCurdy T. and Ozkaynak H. (2008). Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic. Journal of Exposure Science and Environmental Epidemiology 18 (5): 462-476. doi:10.1038/sj.jes.7500637
  39. Isukapalli S.S., Lioy P.J. and Georgopoulos P.G. (2008). Mechanistic modeling of emergency events: Assessing the impact of hypothetical releases of anthrax. Risk Analysis 28 (3): 723-740. doi:10.1111/j.1539-6924.2008.01055.x
  40. Zhu X., Fan Z., Wu X., Meng Q., Wang S.-W., Tang X., Ohman-Strickland P., Georgopoulos P., Zhang J., Bonanno L., Held J. and Lioy P. (2008). Spatial variation of volatile organic compounds in a "Hot Spot" for air pollution. Atmospheric Environment 42 (32): 7329-7338 doi:10.1016/j.atmosenv.2008.07.039
  41. Chen M., Martin J., Fang H., Isukapalli S., Georgopoulos P.G., Welsh W.J. and Tong W. (2009). ebTrack: an environmental bioinformatics system built upon ArrayTrack. BMC Proceedings 3 (Suppl 2): S5. [4]
  42. Georgopoulos P., Isukapalli S., Burke J., Napelenok S., Palma T., Langstaff J., Majeed M., He S., Byun D., Cohen M. and Vautard R. (2009). Air quality modeling needs for exposure assessment from the source-to-outcome perspective. Environmental Manager(October): 26-35. [5]
  43. Georgopoulos P.G. and Isukapalli S.S. (2009). A unified multiscale field/network/agent based modeling framework for human and ecological health risk analysis. Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society 1: 6420-6423. doi:10.1109/IEMBS.2009.5333795
  44. Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2009). Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities. Journal of Exposure Science and Environmental Epidemiology 19 (2): 149-171. doi:10.1038/jes.2008.9
  45. Gerecke D., Chen M., Isukapalli S., Gordon M.K., Chang Y.-C., Tong W., Androulakis I. and Georgopoulos P.G. (2009). Differential gene expression profiling of mouse skin after sulfur mustard exposure: extended time response and inhibitor effect. Toxicology and Applied Pharmacology 234 (2): 156-165. doi:10.1016/j.taap.2008.09.020
  46. Ierapetritou M.G., Georgopoulos P.G., Roth C.M. and Androulakis I.P. (2009). Tissue-level modeling of xenobiotic metabolism in liver: An emerging tool for enabling clinical translational research. Clinical and Translational Science 2 (3): 228 - 237. doi:10.1111/j.1752-8062.2009.00092.x
  47. Laumbach R., Harris G., Kipen H., Georgopoulos P., Shade P., Isukapalli S., Efstathiou C., Galea S., Vlahov D. and Wartenberg D. (2009). Lack of association between estimated World Trade Center plume intensity and respiratory symptoms among New York City residents outside of Lower Manhattan. American Journal of Epidemiology 170 (5): 640-649. doi:10.1093/aje/kwp165
  48. Lioy P.J., Isukapalli S., Trasande L., Thorpe L., Dellarco M., Weisel C., Georgopoulos P.G., Yung C., Brown M. and Landrigan P. (2009). Using national and local extant data to characterize environmental exposures in the National Children’s Study (NCS): Queens County, New York. Environmental Health Perspectives 117 (10): 1494-1504. doi:10.1289/ehp.0900623
  49. Wang S.-W., Tang X., Fan Z., Lioy P.J. and Georgopoulos P.G. (2009). Modeling personal exposures from ambient air toxics in Camden, New Jersey: An evaluation study. Journal of the Air and Waste Management Association 59: 733-746. doi:10.3155/1047-3289.59.6.733
  50. Sasso A., Isukapalli S. and Georgopoulos P. (2010). A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals. Theoretical Biology and Medical Modelling 7 (1): 17. doi:10.1186/1742-4682-7-17
  51. Xue J., Zartarian V., Wang S.W., Liu S.V. and Georgopoulos P.G. (2010). Probabilistic modeling of dietary arsenic exposure and dose and validation with 2003 NHANES data. Environmental Health Perspectives 118 (3): 345-350. doi:10.1289/ehp.0901205
  52. Yang Y., Xu X. and Georgopoulos P.G. (2010). A Bayesian population PBPK model for multiroute chloroform exposure. Journal of Exposure Science and Environmental Epidemiology 20 (4): 326-341. doi:10.1038/jes.2009.29
  53. Sasso A., Isukapalli S. and Georgopoulos P. (2010). A generalized physiologically-based toxicokinetic modeling system for chemical mixtures containing metals. Theoretical Biology and Medical Modelling 7 (1): 17. doi:10.1186/1742-4682-7-17
  54. Hogrefe C., Isukapalli S.S., Tang X., Georgopoulos P.G., He S., Zalewsky E.E., Hao W., Ku J.-Y., Key T. and Sistla G. (2011). Impact of biogenic emission uncertainties on the simulated response of O3 and PM2.5 to anthropogenic emission reductions. Journal of the Air and Waste Management Association 61: 92-108. doi:10.3155/1047-3289.61.1.92
  55. Efstathiou C., Isukapalli S.S. and Georgopoulos P.G. (2011). A mechanistic modeling system for estimating large scale emissions and transport of pollen and co-allergens. Atmospheric Environment 45(13): 2260-2276. doi:10.1016/j.atmosenv.2010.12.008
  56. Stamatelos S.K., Brinkerhoff C.J., Isukapalli S.S. and Georgopoulos P.G. (2011). Mathematical model of uptake and metabolism of arsenic(III) in human hepatocytes – Incorporation of cellular antioxidant response and threshold-dependent behavior. BMC Systems Biology 5 (16). doi:10.1186/1752-0509-5-16
  57. Carter G.P., Miskewitz R.J., Isukapalli S., Mun Y., Vyas V., Yoon S., Georgopoulos P. and Uchrin C.G. (2011). Comparison of kriging and cokriging for the geostatistical estimation of specific capacity in the Newark Basin (NJ) aquifer system. Journal of Environmental Science and Health, Part A: Toxic/Hazardous Substances and Environmental Engineering 46 (4): 371-377. doi:10.1080/10934529.2011.542373

Peer-reviewed book chapters[edit]

Selected from the past 10 years:

  1. Cohen M., Sunderland E., Georgopoulos P.G., Wang S.W., Isukapalli S., Yang Y.C., Sasso A., Tong S., Xue J., McCurdy T., Zhang M., Sheldon L. and International Air Quality Advisory Board (2006). Development of a multicompartment mercury model for Lake Ontario: Tracking mercury from sources, deposition, and dispersion to fish to accumulation in humans. In Priorities 2005 - Priorities and Progress Under the Great Lakes Water Quality Agreenent Windsor, Ontario, Canada, International Joint Commission (IJC): pp. 39–69. [6]
  2. Lioy P.J., Weisel C. and Georgopoulos P.G. (2006). An Overview of the Environmental Conditions and Human Exposures that Occurred Post 9-11. In Urban Aerosols and Their Impacts: Lessons Learned from the World Trade Center Tragedy. Gaffney, J. S. and Marley, N. A. (eds.) Washington DC, ACS Symposium Book, Oxford University Press: pp. 23–38
  3. Isukapalli S.S. and Roy A. (2007). General principles of programming (computer and statistical). In Pharmacometrics: the Science of Quantitative Pharmacology. Ette, E. I. and Williams, P. J. (eds.), Wiley: pp. 25–52. [7]
  4. Isukapalli S.S., Roy A. and Georgopoulos P.G. (2007). Physiologically Based Pharmacokinetic Modeling: Inhalation, Ingestion, and Dermal Absorption. In Pharmacometrics: the Science of Quantitative Pharmacology. Ette, E. I. and Williams, P. J. (eds.), Wiley: pp. 1069–1108. [8]
  5. Welsh W.J., Tong W. and Georgopoulos P.G. (2007). Toxicoinformatics: An Introduction. In Computational Toxicology: Risk Assessment for Pharmaceutical and Environmental Chemicals. Ekins, S. (ed.), Wiley: pp. 153–182. [9]
  6. Fan Z., Lioy P.J. and Wang S.-W. (2008). Ambient Air Quality Monitoring and Community Air Sampling. In Air Sampling Technologies: Principles and Applications Cincinnati, OH, American Conference of Governmental Industrial Hygienists (ACGIH). [10]
  7. Krishnan K., Isukapalli S. and Boyd J. (2009). Evaluation of toxicological interactions for the dose-response assessment of chemical mixtures (Chapter 9). In General and Applied Toxicology. Ballantyne, B., Marrs, T. C. and Syversen, T. (eds.), Wiley/Blackwell. [11]
  8. Georgopoulos P.G., Isukapalli S. and Krishnan K. (2010). Modeling exposures to chemicals from multiple sources and routes. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp. 315–351. [12]
  9. Isukapalli S., Spendiff M., Georgopoulos P.G. and Krishnan K. (2010). Uncertainty, variability and sensitivity analyses in simulation models. In Quantitative Modeling in Toxicology. Krishnan, K. and Andersen, M. E. (eds.), John Wiley: pp. 429–458. [13]
  10. Vallero D., Isukapalli S., Zartarian V., McCurdy T., McKone T., Georgopoulos P.G. and Dary C. (2010). Modeling and predicting pesticide exposures. Chapter 44. In Hayes’ Handbook of Pesticide Toxicology - Third Edition. Krieger, R. (ed.), Academic Press: pp. 995–1020. [14]
  11. Isukapalli S.S., Bielory L. and Georgopoulos P.G. (2011). Modeling effects of climate change on allergic illness. In McGraw-Hill Yearbook of Science and Technology 2011 New York, McGraw-Hill: pp. 205–208
  12. Krishnan K., Sasso A. and Georgopoulos P.G. (2010). Pharmacokinetic mechanisms of interactions in chemical mixtures. In Principles and Practice of Mixture Toxicology. Mumtaz, M. (ed.), John Wiley Publishers: pp. 159–176. [15]
  13. Georgopoulos P.G., Isukapalli S., Androulakis I.P., Ierapetritou M.G. and Welsh W.J. (2011). Multiscale integration of toxicokinetic and toxicodynamic processes: From cell and tissue to organ and "whole body" models. In Handbook of Systems Toxicology. Casciano, D. and Sahu, S. (eds.), John Wiley. pp. 619–668 [16]

Government reports[edit]

  1. Isukapalli S.S. and Georgopoulos P.G. (2001). Computational Methods for Sensitivity and Uncertainty Analysis for Environmental and Biological Models. Research Triangle Park, NC. Prepared for the US Environmental Protection Agency National Exposure Research Laboratory. EPA/600/R-01-068 (145 pp.). [17]
  2. Small M.J., Anderson H.A., Bartell S.M., Chien C., Greer L.E., Liu K.S., Mauderly J.L., Middleton P., Brown D.R., Gentile T.J., Georgopoulos P.G., Henry C.J., Millford J., Kooyoomjian K.J. and Fortune B.B. (2001). NATA - Evaluating the National-Scale Air Toxics Assessment 1996 Data - an SAB Advisory. Prepared for US EPA's Science Advisory Board. EPA-SAB-EC-ADV-02-001 (62 pp. plus appendices)
  3. USEPA (2006). Draft Guidance on the Development, Evaluation, and Application of Regulatory Environmental Models and Models Knowledge Base [P.G. Georgopoulos, Contributor] Washington DC. Regulatory Environmental Modeling Guidance Review Panel, EPA Science Advisory Board. EPA-SAB-06-009. [18]
  4. Kotchmar D.J., Ross M., Belanger K., Brown J.S., Bryant D., Cote I., Frampton M., Gent J., Hasselblad V., Ito K., Kim J.Y., Kirrane E., Luben T., Maier A., Meng Q., Pinto J., Reinhart P., Svendsgaard D., White L., Allen D., Arnold J., Camalier L., Dickerson R., Fan T., Fiore A., Georgopoulos P., Horowitz L., Keene W., Martin R., Morandi M., Munger W., Piety C., Sillman S., Suh H., Walsh D., Wechsler C., Weisel C. and Zhang J. (2007). Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (First External Review Draft). Research Triangle Park, NC. USEPA National Center for Environmental Assessment. EPA/600/R-07/093 (371 pages). [19]
  5. USEPA (2007). Report on the External Peer Review Workshop of EPA’s Draft Document Child-Specific Exposure Factors Handbook [P.G. Georgopoulos, Contributor] Washington DC. US Environmental Protection Agency (80 pages)
  6. USEPA (2008). Integrated Science Assessment for Oxides of Nitrogen – Health Criteria (Final) [P.G. Georgopoulos, Contributor] Research Triangle Park, NC. USEPA National Center for Environmental Assessment. EPA/600/R-08/07 (260 pages). [20]
  7. USEPA (2008). Integrated Science Assessment for Sulfur Oxides – Health Criteria (Final Report). Washington, DC. US Environmental Protection Agency. EPA/600/R-08/047F (479 pages). [21]

Books[edit]

  1. Georgopoulos P.G., Roy A., Yonone-Lioy M.J., Opiekun R.E. and Lioy P.J. (2002). Environmental Dynamics and Human Exposure to Copper Volume 1: Environmental Dynamics and Human Exposure Issues. New York, NY, International Copper Association. ISBN 09436421213
  2. Georgopoulos P.G., Wang S.W., Vyas V.M., Lioy P.J., Tan H.C., Georgopoulos I.G. and Yonnone-Lioy J. (2002). Environmental Dynamics and Human Exposure to Copper Volume 2: Framework and Data Sources for Assessing Human Exposure to Copper in the United States. New York, NY, International Copper Association. ISBN 09436421214

References[edit]

  1. ^ Georgopoulos P.G., Wang S.W., Vyas V.M., Sun Q., Burke J., Vedantham R., McCurdy T. and Ozkaynak H. (2005). A source-to-dose assessment of population exposures to fine PM and ozone in Philadelphia, PA, during a summer 1999 episode. Journal of Exposure Analysis and Environmental Epidemiology 15(5): 439−457
  2. ^ Georgopoulos P.G. and Lioy P.J. (2006). From theoretical aspects of human exposure and dose Assessment to computational model implementation: The MOdeling ENvironment for TOtal Risk studies (MENTOR). Journal of Toxicology and Environmental Health - Part B, Critical Reviews 9(6): 457-483
  3. ^ a b Georgopoulos P. (2008). A multiscale approach for assessing the interactions of environmental and biological systems in a holistic health risk assessment framework. Water, Air, and Soil Pollution: Focus 8(1): 3-21. doi:10.1007/s11267-007-9137-7
  4. ^ Georgopoulos P.G., Wang S.-W., Yang Y.-C., Xue J., Zartarian V.G., McCurdy T. and Ozkaynak H. (2008). Biologically based modeling of multimedia, multipathway, multiroute population exposures to arsenic. Journal of Exposure Science and Environmental Epidemiology 18(5): 462-476
  5. ^ Georgopoulos P.G., Sasso A.F., Isukapalli S.S., Lioy P.J., Vallero D.A., Okino M. and Reiter L. (2009). Reconstructing population exposures to environmental chemicals from biomarkers: Challenges and opportunities. Journal of Exposure Science and Environmental Epidemiology 19(2): 149-171. doi:10.1038/jes.2008.9
  6. ^ Georgopoulos P.G., Isukapalli S., Androulakis I.P., Ierapetritou M.G. and Welsh W.J. (2011). Multiscale integration of toxicokinetic and toxicodynamic processes: From cell and tissue to organ and "whole body" models. In Handbook of Systems Toxicology. Casciano, D. and Sahu, S. (eds.), John Wiley & Sons: pp.619-668

External links[edit]