Pantothenate kinase

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Pantothenate kinase
Identifiers
EC number 2.7.1.33
CAS number 9026-48-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Pantothenate kinase (EC 2.7.1.33, PanK; CoaA) is the first enzyme in the Coenzyme A biosynthetic pathway. It phosphorylates pantothenate (vitamin B5) to form 4'-phosphopantothenate.

Types[edit]

Three distinct types of PanK has been identified - PanK-I (found in bacteria), PanK-II (mainly found in eukaryotes, but also in the Staphylococci) and PanK-III, also known as CoaX (found in bacteria). Eukaryotic PanK-II enzymes often occur as different isoforms, such as PanK1, PanK2, PanK3 and PanK4.

Genes[edit]

PANK2 mutation is the cause of Pantothenate kinase-associated neurodegeneration, formerly called Hallervorden-Spatz syndrome. This rare disease presents with profound dystonia, spasticity and is often fatal.

External links[edit]