Cirino Pomicino was born in Naples. He graduated in Medicine and Surgery and entered Democrazia Cristiana (Italian Christian Democracy, or DC) for which he became first a member of Naples' city council, and then member of the Italian Chamber of Deputies in 1976, a position he held until 1994.
A member of Giulio Andreotti's corrente (political movement within DC), he was under minister of the Public Functions (1988-1989) and Minister of the Economical Balance (1989-1992). He was nicknamed o' ministro ("The minister" in Neapolitan dialect). During his membership of DC, he has been convicted for illegal financing (sentenced to 1 year and 8 months) and he negotiated (thereby admitting guilt) 2 months for corruption and hidden funds. He was also involved in the scandal of the funds management for the reconstruction after the 1980 Irpinia earthquake.