Papilloma

Papilloma
Classification and external resources
Intraductal papilloma of breast, H&E, 10x
ICD-O:	8050/0
MeSH	D010212

Papilloma refers to a benign epithelial tumor growing exophytically (outwardly projecting) in finger-like fronds. In this context papilla refers to the projection created by the tumor, not a tumor on an already existing papilla (such as the nipple). When used without context, it frequently refers to infections (squamous cell papilloma) caused by human papillomavirus (HPV), such as warts. There are, however, a number of other conditions that cause papilloma, as well as many cases in which there is no known cause.

Human papillomavirus infection is a major cause of cervical cancer, although most HPV infections do not cause cancer.

Description

A benign papillomatous tumor derived from epithelium. Cauliflower-like projections that arise from the mucosal surface. It may appear white or normal colored. It may be pedunculated or sessile. The average size is less than 2.0 cm. No strong sex preference. The most common site was the palate-uvula area followed by tongue and lips. The durations ranged from weeks to 10 years.

Etiology

Immunoperoxidase stains have identified antigens of the human papillomavirus (HPV) types 6 and 11 in approximately 50% of cases.

Prognosis

Good, there is no evidence that papillomas are premalignant.

Differential diagnosis

• Intraoral verruca vulgaris,
• Condyloma acuminatum, and
• Focal epithelial hyperplasia.

Note: differentiation is done accurately by microscopic examination only.

Treatment

Conservative surgical excision, recurrence is rare.

See also

• Inverted papilloma
• Squamous cell papilloma
• Intraductal papilloma of breast
• Wart
  • Genital wart
  • Plantar wart
• Papillomavirus
  • Human papillomavirus

External links

• Choroid Plexus Papilloma - Palmer, Cheryl Ann and Daniel Keith Harrison; EMedicine; Jun 5, 2008
• Types of papilloma
• Squamous cell papilloma
• iv_2/p/PAPILLOMA_BLADDER article at GE's Medcyclopaedia