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This article is about the organism. For for the infection, see Helminthiasis.
Hookworms attached to the intestinal mucosa

Helminths (/ˈhɛlmɪnθs/) are large multicellular organisms, which when mature can generally be seen with the naked eye. An infection by a Helminth is known as helminthiasis, helminth infection or intestinal worm infection.

They are worm-like organisms living in and feeding on living hosts, receiving nourishment and protection while disrupting their hosts' nutrient absorption, causing weakness and disease. Those that live inside the digestive tract are called intestinal parasites. They can live inside humans and other animals.

Helminthology is the study of parasitic worms and their effects on their hosts. The word helminth comes from Greek hélmins, a kind of worm.


Helminths is a polyphyletic group of morphologically similar organisms, consisting of members of the following taxa: monogeneans, cestodes (tapeworms), nematodes (roundworms), and trematodes (flukes). The following table shows the principal morphological distinctions for each of these helminth families:

Tapeworms (Cestodes) Flukes (Trematodes) Roundworms (Nematodes)
Shape Segmented plane Unsegmented plane Cylindrical
Body cavity No No Present
Body covering Tegument Tegument Cuticle
Digestive tube No Ends in cecum Ends in anus
Sex Hermaphroditic Hermaphroditic, except schistosomes which are dioecious Dioecious
Attachment organs Sucker or bothridia, and rostellum with hooks Oral sucker and ventral sucker or acetabulum Lips, teeth, filariform extremities, and dentary plates
Example diseases in humans Tapeworm infection Schistosomiasis, swimmer's itch Ascariasis, dracunculiasis (guinea worm), elephantiasis, enterobiasis (pinworm), filariasis, hookworm, onchocerciasis, trichinosis, trichuriasis (whipworm)

Note: ringworm (dermatophytosis) is actually caused by various fungi and not by a parasitic worm.

Use in medicine[edit]

Main article: Helminthic therapy

Parasitic worms have been used as a medical treatment for various diseases, particularly those involving an overactive immune response.[1] As humans have evolved with parasitic worms, proponents argue they are needed for a healthy immune system.[1] Scientists are looking for a connection between the prevention and control of parasitic worms and the increase in allergies such as hay-fever in developed countries.[1] Parasitic worms may be able to damp down the immune system of their host, making it easier for them to live in the intestine without coming under attack.[1] This may be one mechanism for their proposed medicinal effect.

One study suggests a link between the rising rates of metabolic syndrome in the developed worlds and the largely successful efforts of Westerners to eliminate intestinal parasites. The work suggests eosinophils (a type of white blood cell) in fat tissue play an important role in preventing insulin resistance by secreting interleukin 4, which in turn switches macrophages into "alternative activation". Alternatively-activated macrophages are important to maintaining glucose homeostasis (i.e., blood sugar regulation). Helminth infection causes an increase in eosinophils. In the study, the authors fed rodents a high-fat diet to induce metabolic syndrome, and then injected them with helminths. Helminth infestation improved the rodents' metabolism.[2] The authors concluded:

Although sparse in blood of persons in developed countries, eosinophils are often elevated in individuals in rural developing countries where intestinal parasitism is prevalent and metabolic syndrome rare. We speculate that eosinophils may have evolved to optimize metabolic homeostasis during chronic infections by ubiquitous intestinal parasites….[2]

Indicator in sanitation[edit]

In the realm of sanitation - e.g. for treatment and reuse of faecal sludge or dried faecal matter - the presence or absence of viable helminth eggs (also called ova) in a sample of dried faecal matter, compost or faecal sludge is often used as an indicator on how well a treatment process has killed off pathogens because helminth eggs are harder to destroy than any other pathogen (i.e. bacteria, protozoa, viruses). In particular, the number of viable Ascaris eggs are often taken as an indicator organism in treatment processes. The detection of viable helminth eggs in samples is not always straight forward and many laboratories in developing countries lack the right equipment or the skilled staff required to do so.



  1. ^ a b c d "Eat worms - feel better". BBC News. 3 December 2003. Retrieved 13 July 2011. 
  2. ^ a b Wu, Davina; et al. (8 April 2011). "Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis". Science 332 (6026): 243–247. doi:10.1126/science.1201475. PMC 3144160. PMID 21436399. Retrieved 18 April 2011. 

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