Parathyroid hormone 2 receptor

Parathyroid hormone 2 receptor
Identifiers
Symbols	PTH2R; PTHR2
External IDs	OMIM: 601469 MGI: 2180917 HomoloGene: 3701 IUPHAR: PTH2 GeneCards: PTH2R Gene
Gene Ontology Molecular function • signal transducer activity • receptor activity • parathyroid hormone receptor activity Cellular component • plasma membrane • integral to plasma membrane Biological process • G-protein coupled receptor signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5746	213527
Ensembl	ENSG00000144407	ENSMUSG00000025946
UniProt	P49190	Q91V95
RefSeq (mRNA)	NM_005048.2	NM_139270.2
RefSeq (protein)	NP_005039.1	NP_644676.1
Location (UCSC)	Chr 2: 209.22 – 209.72 Mb	Chr 1: 65.33 – 65.44 Mb
PubMed search	[1]	[2]

Parathyroid hormone 2 receptor is a protein that in humans is encoded by the PTH2R gene

Function

The protein encoded by this gene is a member of the G protein-coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone 1 receptor (PTH1R). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.

See also

• Parathyroid hormone receptor

Further reading

• Usdin TB, Gruber C, Bonner TI (1995). "Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.". J. Biol. Chem. 270 (26): 15455–8. doi:10.1074/jbc.270.26.15455. PMID 7797535. 
• Usdin TB, Modi W, Bonner TI (1997). "Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.". Genomics 37 (1): 140–1. doi:10.1006/geno.1996.0532. PMID 8921382. 
• Clark JA, Bonner TI, Kim AS, Usdin TB (1998). "Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.". Mol. Endocrinol. 12 (2): 193–206. doi:10.1210/me.12.2.193. PMID 9482662. 
• Hoare SR, Clark JA, Usdin TB (2000). "Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.". J. Biol. Chem. 275 (35): 27274–83. doi:10.1074/jbc.M003910200. PMID 10854439. 
• John MR, Arai M, Rubin DA, et al. (2002). "Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.". Endocrinology 143 (3): 1047–57. doi:10.1210/en.143.3.1047. PMID 11861531. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Seeliger S, Hausberg M, Eue I, et al. (2003). "The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.". Clin. Nephrol. 59 (6): 429–35. PMID 12834174. 
• Bisello A, Manen D, Pierroz DD, et al. (2004). "Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.". Mol. Endocrinol. 18 (6): 1486–98. doi:10.1210/me.2003-0487. PMID 14988434. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Mahon MJ, Shimada M (2005). "Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.". FEBS Lett. 579 (3): 803–7. doi:10.1016/j.febslet.2004.12.056. PMID 15670850. 

External links

• "Parathyroid Hormone Receptors: PTH2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2970. 
• MeSH Receptor,+Parathyroid+Hormone,+Type+2

This article incorporates text from the United States National Library of Medicine, which is in the public domain.