Parkers Marsh Natural Area Preserve is a 759-acre (307 ha) Natural Area Preserve located in Accomack County, Virginia. The preserve incorporates beach habitat along the Chesapeake Bay as well as low marsh, high marsh, shrubs, and forest vegetation; the wetlands provide a home for many different species of animals and plants. About 75% of the site is saltmarsh. Marsh elder and black cherry may be found on old dune ridges on the site, as may loblolly pine. Some lower dunes support various grassland species. Peregrine falcons have nested in the area since 1998, and the rare Saltmarsh Sparrow has been observed nesting at the site. In addition, the beach provides a home for the northeastern beach tiger beetle.
The preserve has been designated an Audubon Important Bird Area as a part of the Delmarva Bayside Marshes IBA.